|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pre-surgery ApoB was an independent prognosis predicting factor with HR as 1.396 (<i>P</i>=0.033), elevated ApoB was associated with worse postsurgery prognosis in HCC patients.
|
30881047 |
2019 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study examined the relationships between the single nucleotide polymorphisms (SNPs) of three members of the apolipoprotein B mRNA‑editing catalytic polypeptide‑like 3 (A3) gene family, A3A, A3B and A3H, and hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) in a Han Chinese population.
|
31322199 |
2019 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOB inactivation was associated with poor prognosis when the APOB gene signature was applied in all human HCC cohorts.
|
30429453 |
2018 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, rare loss-of-function mutations in Apolipoprotein B resulting in very low density lipoproteins hepatic retention and in Telomerase reverse transcriptase influencing cellular senescence have also been linked to HCC in NAFLD.
|
25278690 |
2014 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that GSPE inhibited TG and ApoB secretion in human hepatocarcinoma HepG2 cells and had and hypotriglyceridemic effect in wild-type mouse.
|
18720348 |
2008 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An expression vector with a constitutively active form of Akt1 was transfected in the rat hepatoma McArdle cells (McA RH-7777), McA cells stably expressing human apoB-15 and apoB-48 (15% and 48% of total apoB length), and human hepatoma HepG2.
|
14767876 |
2004 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the rat hepatoma McArdle cell line, these sites occurred predominantly 5' of the mooring sequence on either rat or human apoB mRNA expressed from transfected cDNA.
|
9512534 |
1998 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
15: 198-207) examining stable integration of some of our constructs into human and rat hepatoma transfectants suggest that in single and double copy transfectants, the apoB MARs behave as boundary "insulators", protecting the integrated transgenes against position effects regardless of their site of integration.
|
8906589 |
1996 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Level of apolipoprotein B mRNA has an important effect of the synthesis and secretion of apolipoprotein B-containing lipoproteins. Studies on transfected hepatoma cell lines expressing recombinant human apolipoprotein B.
|
7583570 |
1995 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of recombinant human apoB-48-containing lipoproteins in rat hepatoma McA-RH7777 cells transfected with apoB-48 cDNA. Overexpression of apoB-48 decreases synthesis of endogenous apoB-100.
|
7749860 |
1995 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin modulation of apolipoprotein B gene expression was studied at the translational level by the use of a cell-free translation system from a hepatoma cell-line, HepG2.
|
1338569 |
1992 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein B genetic polymorphisms in several human hepatoma derived liver cell lines.
|
1348933 |
1992 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These two proximal regions located between -128 and -70 appear to act together to determine the cell type-specific expression of the apoB gene in HepG2 and HeLa cells.
|
3165376 |
1988 |