|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
Hypertension was induced by administering an infusion of Ang II (1000 ng/kg/min) to wild-type (WT) mice treated with an IgG control or ICAM-1 neutralizing antibody (1 and 2 mg/mouse/day, respectively).
|
31527830 |
2020 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor antigen (vWF<sub>ag</sub>)) are associated with IGF-1 in a healthy study population forming part of the larger African Prospective study on the Early Detection and Identification of Cardiovascular diseases and Hypertension (African-PREDICT).
|
29936324 |
2018 |
|
Hypertensive disease
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Multivariate analysis revealed that ICAM-1 SNP rs281432 CC/CG [p=0.016; odds ratio (OR): 2.56, 95% confidence interval (CI): 1.19-5.56], male gender (p=0.018; OR: 1.66, 95% CI: 1.09-2.51), aspirin use in the past 7 days (p=0.001; OR: 2.05, 95% CI: 1.33-3.14), hypertension (p<0.001; OR: 2.15, 95% CI: 1.42-3.25), serum cardiac troponin I elevation (p<0.001; OR: 2.14, 95% CI: 1.47-3.24) and severe angina in recent 24 hours (p=0.001; OR: 1.97, 95% CI: 1.31- 2.95) increase the risk of CAD.
|
26078712 |
2015 |
|
Hypertensive disease
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Finally, among those with coronary atherosclerosis, we found no differences in the haplotype analysis of polymorphisms of the ICAM-1 gene from individuals with hypertension or those who smoked.
|
25310099 |
2014 |
|
Hypertensive disease
|
0.370 |
GeneticVariation
|
group |
BEFREE |
K469E gene polymorphism of ICAM-1 was related to ACS recurrence and cardiovascular mortality, K allele probably an independent risky factor and hypertension and to which the level of HDL-C were closely related.
|
24083591 |
2013 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension.
|
19078988 |
2009 |
|
Hypertensive disease
|
0.370 |
AlteredExpression
|
group |
BEFREE |
Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se.
|
15448102 |
2004 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
CTD_human |
Patients with uncomplicated hypertension with no other risk factors of atherosclerosis had significantly elevated levels of ICAM-1, vWf, and endothelin-1.
|
12149661 |
2002 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
CTD_human |
[Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy].
|
12425201 |
2002 |