C1QTNF9, C1q and TNF related 9, 338872

N. diseases: 30; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.050 AlteredExpression disease BEFREE In addition, CTRP9 downregulated the expressions of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α), two main proinflammatory cytokines in atherosclerosis. 30426302 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.050 AlteredExpression disease BEFREE However, whether the CTRP9 affects the activity of NLRP3 inflammasome during the atherosclerosis development remains unclear, which would be elucidated in the current study. 31727560 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 AlteredExpression disease BEFREE However, whether the CTRP9 affects the activity of NLRP3 inflammasome during the atherosclerosis development remains unclear, which would be elucidated in the current study. 31727560 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 AlteredExpression disease BEFREE In addition, CTRP9 downregulated the expressions of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α), two main proinflammatory cytokines in atherosclerosis. 30426302 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.050 Biomarker disease BEFREE Conclusions This study provides the first evidence that the long-term existence of β<sub>1</sub>- AA mAb suppresses cardiac CTRP 9 expression and exaggerates cardiac remodeling, suggesting that CTRP 9 may be a novel therapeutic target against pathologic remodeling in β<sub>1</sub>- AA -positive patients with coronary heart disease. 30764693 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.050 Biomarker disease BEFREE In this review, we summarize the latest advances regarding the roles of CTRP9 in atherosclerosis with an emphasis on its potential as a novel therapeutic target in cardiovascular disease. 30056359 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.050 Biomarker disease BEFREE These results show that CTRP9 protects against atherosclerosis by promoting cholesterol efflux to reduce the formation of foam cell in virtue of inducing autophagy in an AMPK/mTOR signaling pathway-dependent manner. 29979351 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE These results show that CTRP9 protects against atherosclerosis by promoting cholesterol efflux to reduce the formation of foam cell in virtue of inducing autophagy in an AMPK/mTOR signaling pathway-dependent manner. 29979351 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE In this review, we summarize the latest advances regarding the roles of CTRP9 in atherosclerosis with an emphasis on its potential as a novel therapeutic target in cardiovascular disease. 30056359 2018
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.050 Biomarker disease BEFREE Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females. 30557342 2018
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.050 AlteredExpression disease BEFREE Circulating CTRP9 levels are significantly decreased in patients with coronary atherosclerosis disease. 30056359 2018
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.050 Biomarker disease BEFREE Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease. 29381773 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.050 Biomarker disease BEFREE CTRP9 independently trends in a different manner from HAN, and may reflect diabetic renal vascular risk in association with atherosclerosis and abnormal glucose metabolism besides of impaired vaso-relaxation in patients with T2DM. 26633552 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE CTRP9 independently trends in a different manner from HAN, and may reflect diabetic renal vascular risk in association with atherosclerosis and abnormal glucose metabolism besides of impaired vaso-relaxation in patients with T2DM. 26633552 2017
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.050 Biomarker disease BEFREE Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. 26457306 2015
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.040 Biomarker disease BEFREE <b>Conclusions:</b> This study provides the first evidence that MI+CIH upregulates miR-214-3p, suppresses cardiac CTRP9 expression, and exacerbates cardiac remodeling, suggesting that CTRP9 may be a novel therapeutic target against pathologic remodeling in MI patients with OSA. 31694459 2020
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.040 Biomarker disease BEFREE C1q/TNF-related protein-9 (CTRP9) has anti-inflammatory effects and can ameliorate heart function in mice after long-term myocardial infarction. 30953351 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.040 Biomarker disease BEFREE CTRP9 (C1q/tumor necrosis factor-related protein-9) as a secreted glycoprotein can reverse left ventricle remodeling post-MI, but its effects on MI-induced atrial inflammation, fibrosis, and associated AF are unknown. 31623508 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.040 Biomarker disease BEFREE Conclusions This study provides the first evidence that the long-term existence of β<sub>1</sub>- AA mAb suppresses cardiac CTRP 9 expression and exaggerates cardiac remodeling, suggesting that CTRP 9 may be a novel therapeutic target against pathologic remodeling in β<sub>1</sub>- AA -positive patients with coronary heart disease. 30764693 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 Biomarker group BEFREE In this review, we summarize the latest advances regarding the roles of CTRP9 in atherosclerosis with an emphasis on its potential as a novel therapeutic target in cardiovascular disease. 30056359 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 Biomarker group BEFREE As a novel adipokine, C1q/tumor necrosis factor-related protein-9 (CTRP9) has beneficial effects in cardiovascular disease. 29979351 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.040 AlteredExpression disease BEFREE The results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this. 29381773 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.040 Biomarker disease BEFREE Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females. 30557342 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.040 AlteredExpression disease BEFREE The results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this. 29381773 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 Biomarker group BEFREE C1q/TNF-related protein 9 (CTRP9) is a recently discovered adipokine that has been shown to have beneficial effects on glucose metabolism and vascular function, particularly in regard to cardiovascular disease. 28524645 2017