|
Obesity
|
0.200 |
Biomarker
|
disease |
RGD |
In contrast, the hepatic mRNA encoding APOBEC-1, the catalytic subunit of the RNA editing activity, demonstrated an increased abundance of 1.8-fold in obese Zucker rats versus lean controls.
|
8781289 |
1996 |
|
Hypercholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, in apoE-/- mice, inactivation of apobec-1 caused a massive increase (from <0.5 to 55.5+/-16.4 mg/dL) in plasma apoB-100 concentration but an approximately 55% reduction in hypercholesterolemia due to partial amelioration of the marked VLDL+IDL elevation.
|
9598833 |
1998 |
|
Liver and Intrahepatic Bile Duct Epithelial Neoplasm
|
0.200 |
Biomarker
|
disease |
RGD |
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
|
9633945 |
1998 |
|
Liver and Intrahepatic Bile Duct Neoplasm
|
0.200 |
Biomarker
|
disease |
RGD |
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
|
9633945 |
1998 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
RE4 APOBEC-1 transgenic mice should prove valuable for studying the roles of apoB-containing lipoproteins in lipid metabolism and atherosclerosis.
|
9633945 |
1998 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
RE4 APOBEC-1 transgenic mice should prove valuable for studying the roles of apoB-containing lipoproteins in lipid metabolism and atherosclerosis.
|
9633945 |
1998 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, high-level expression of APOBEC-1 in transgenic mouse and rabbit livers causes liver dysplasia and hepatocellular carcinoma.
|
9633945 |
1998 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These results indicates that long-term hepatic expression of APOBEC-1 at low levels sufficient to eliminate LDL does not cause apparent liver damage or liver tumors in transgenic mice.
|
9633945 |
1998 |
|
Malignant tumor of colon
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Apobec-1 mRNA was detectable in normal and colon cancer tissue, metastatic nodules, and certain colon cancer-derived cell lines.
|
9797364 |
1998 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Apobec-1 is an RNA-specific cytidine deaminase whose forced overexpression in transgenic animals is associated with hepatic carcinogenesis.
|
9797364 |
1998 |
|
Gastrointestinal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Apobec-1 messenger RNA (mRNA) undergoes alternative splicing, generating a catalytically inactive peptide, apobec-T. We have examined apobec-1 gene expression in human gastrointestinal tumors and in colon cancer-derived cell lines.
|
9797364 |
1998 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Apobec-1 mRNA was detectable in normal and colon cancer tissue, metastatic nodules, and certain colon cancer-derived cell lines.
|
9797364 |
1998 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Currently, there is no evidence that aberrant editing mediated by APOBEC-1 contributes to the tumorigenesis of natural human carcinomas.
|
10597235 |
1999 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The transgene expression of the catalytic subunit APOBEC-1 of the apo B mRNA editing enzyme-complex can cause hepatocellular carcinoma in mice and rabbits.
|
10597235 |
1999 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Currently, there is no evidence that aberrant editing mediated by APOBEC-1 contributes to the tumorigenesis of natural human carcinomas.
|
10597235 |
1999 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The 'auxiliary' components of the apo B mRNA editing enzyme-complex are missing in many tumors including colorectal and gastric carcinoma, but are highly expressed in hepatocellular, lung adeno- and breast carcinoma all of which lack APOBEC-1.
|
10597235 |
1999 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Overexpression of APOBEC-1 in transgenic animals caused liver dysplasia and APOBEC-1 has been identified in neurofibromatosis type 1 tumours, suggesting that RNA editing may be another mechanism for tumourigenesis.
|
11072063 |
2000 |
|
Neurofibromatosis 1
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overexpression of APOBEC-1 in transgenic animals caused liver dysplasia and APOBEC-1 has been identified in neurofibromatosis type 1 tumours, suggesting that RNA editing may be another mechanism for tumourigenesis.
|
11072063 |
2000 |
|
Hyperlipidemia
|
0.200 |
Biomarker
|
disease |
RGD |
Effects of a thyromimetic on apolipoprotein B-100 in rats.
|
11116209 |
2000 |
|
Hyperlipoproteinemias
|
0.200 |
Biomarker
|
disease |
RGD |
Effects of a thyromimetic on apolipoprotein B-100 in rats.
|
11116209 |
2000 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
First, these tumors express apobec-1 mRNA, the first demonstration, in humans, of its expression beyond the luminal gastrointestinal tract.
|
11727199 |
2002 |
|
Neurofibromatosis 1
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
|
11727199 |
2002 |
|
Neurofibromatosis 1
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Taken together, the data support the hypothesis that C-->U RNA editing of the NF1 transcript occurs both in a subset of PNSTs and in an alternatively spliced form containing a downstream exon, presumably an optimal configuration for enzymatic deamination by apobec-1.
|
11727199 |
2002 |
|
Malignant tumor of colon
|
0.210 |
Biomarker
|
disease |
RGD |
In colon cancer, apobec-1 protein levels decreased by 90% in the cancer tissue as compared to normal tissue, suggesting an inhibitory effect of the 5'UTR on apobec-1 translation.
|
12020819 |
2002 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Members of the APOBEC (apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1-like) family of cytidine deaminases inhibit host cell genome invasion by exogenous retroviruses and endogenous retrotransposons.
|
17166910 |
2007 |