|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Malignant tumor of colon
|
0.210 |
Biomarker
|
disease |
RGD |
In colon cancer, apobec-1 protein levels decreased by 90% in the cancer tissue as compared to normal tissue, suggesting an inhibitory effect of the 5'UTR on apobec-1 translation.
|
12020819 |
2002 |
|
Malignant tumor of colon
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Apobec-1 mRNA was detectable in normal and colon cancer tissue, metastatic nodules, and certain colon cancer-derived cell lines.
|
9797364 |
1998 |
|
Hyperlipidemia
|
0.200 |
Biomarker
|
disease |
RGD |
Effects of a thyromimetic on apolipoprotein B-100 in rats.
|
11116209 |
2000 |
|
Hyperlipoproteinemias
|
0.200 |
Biomarker
|
disease |
RGD |
Effects of a thyromimetic on apolipoprotein B-100 in rats.
|
11116209 |
2000 |
|
Liver and Intrahepatic Bile Duct Epithelial Neoplasm
|
0.200 |
Biomarker
|
disease |
RGD |
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
|
9633945 |
1998 |
|
Liver and Intrahepatic Bile Duct Neoplasm
|
0.200 |
Biomarker
|
disease |
RGD |
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
|
9633945 |
1998 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
RGD |
In contrast, the hepatic mRNA encoding APOBEC-1, the catalytic subunit of the RNA editing activity, demonstrated an increased abundance of 1.8-fold in obese Zucker rats versus lean controls.
|
8781289 |
1996 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
APOBEC1 emerged as the mere consistently hypomethylated gene in tumor samples with high number of in-frame indels.
|
29346513 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
This includes the repression of a network of GTPase-related genes (Prkg1, Gnao1 and Rgs9) in tumor samples and an enrichment of Apobec1-mediated cytosine to uridine RNA editing.
|
24317514 |
2015 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Moreover, we find the presence of an AID/APOBEC mutational signature in esophageal adenocarcinomas, a type of tumor where APOBEC1 is expressed, that mimics the one preferred by APOBEC1 in vitro.
|
25085003 |
2014 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
This reduced tumor burden was found in association with increased small intestinal apoptosis and reduced proliferation in small intestinal crypt-villus units from compound Apc(min/+) apobec-1(-/-) mice.
|
17875695 |
2007 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
First, these tumors express apobec-1 mRNA, the first demonstration, in humans, of its expression beyond the luminal gastrointestinal tract.
|
11727199 |
2002 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Overexpression of APOBEC-1 in transgenic animals caused liver dysplasia and APOBEC-1 has been identified in neurofibromatosis type 1 tumours, suggesting that RNA editing may be another mechanism for tumourigenesis.
|
11072063 |
2000 |
|
Carcinogenesis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
At an experimental level mouse APOBEC1 is remarkable among 12 mammalian A1 enzymes in that it represents a source of somatic mutations in mouse genome, potentially fueling oncogenesis.
|
31726973 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
APOBEC1 could be involved in cancer promotion at the very early stages of carcinogenesis, as it is highly expressed in Barrett's esophagus, a condition often associated with esophageal adenocarcinoma.
|
25085003 |
2014 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Currently, there is no evidence that aberrant editing mediated by APOBEC-1 contributes to the tumorigenesis of natural human carcinomas.
|
10597235 |
1999 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Apobec-1 is an RNA-specific cytidine deaminase whose forced overexpression in transgenic animals is associated with hepatic carcinogenesis.
|
9797364 |
1998 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we placed hypercholesterolemic Ldlr-/-Apobec1-/- mice on a high-fat diet and treated them with either 25 mg/kg/day of clopidogrel (CLO) or 180 mg/kg/day of TIC for 16 weeks and evaluated the extent of atherosclerosis.
|
31242230 |
2019 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we placed hypercholesterolemic Ldlr-/-Apobec1-/- mice on a high-fat diet and treated them with either 25 mg/kg/day of clopidogrel (CLO) or 180 mg/kg/day of TIC for 16 weeks and evaluated the extent of atherosclerosis.
|
31242230 |
2019 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
However, among all the enzymes studied, mouse A1 appears to be singular, being able to introduce somatic mutations into nuclear DNA with a clear 5'TpC editing context, and to deaminate 5-methylcytidine substituted DNA which are characteristic features of the cancer related mammalian A3A and A3B enzymes.
|
31726973 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
However, among all the enzymes studied, mouse A1 appears to be singular, being able to introduce somatic mutations into nuclear DNA with a clear 5'TpC editing context, and to deaminate 5-methylcytidine substituted DNA which are characteristic features of the cancer related mammalian A3A and A3B enzymes.
|
31726973 |
2019 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The correlation of APOBEC1 expression levels with cancer indels was independent of age and defects in DNA homologous recombination (HR) and/or mismatch repair.
|
29346513 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The correlation of APOBEC1 expression levels with cancer indels was independent of age and defects in DNA homologous recombination (HR) and/or mismatch repair.
|
29346513 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
APOBEC1 could be involved in cancer promotion at the very early stages of carcinogenesis, as it is highly expressed in Barrett's esophagus, a condition often associated with esophageal adenocarcinoma.
|
25085003 |
2014 |