IRF8, interferon regulatory factor 8, 3394

N. diseases: 149; N. variants: 20
Disease: Behcet Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.030 AlteredExpression disease BEFREE We found a lower mRNA expression and a higher methylation level of IRF8 in active ocular BD patients as compared to normal subjects and inactive patients. 28881647 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.030 AlteredExpression disease BEFREE Aberrant methylation change of IRF8 confers risk to various tumors, and abnormal expression of IRF8 is involved in many autoimmune diseases, including ocular Behcet's disease. 28432342 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.030 GeneticVariation disease BEFREE Two SNPs near IRF8 were associated with BD (for rs17445836 GG genotype, Pc = 9.56 × 10(-8), OR = 2.044; for rs11642873 AA genotype, Pc = 9.24 × 10(-7), OR = 1.776). 26794091 2016