IRF8, interferon regulatory factor 8, 3394

N. diseases: 149; N. variants: 20
Disease: Mycobacterium Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026918
Disease: Mycobacterium Infections
Mycobacterium Infections 		0.030 Biomarker group BEFREE So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection. 26049967 2015
CUI: C0026918
Disease: Mycobacterium Infections
Mycobacterium Infections 		0.030 Biomarker group BEFREE Genetic determinants of susceptibility to Mycobacterial infections: IRF8, a new kid on the block. 23468103 2013
CUI: C0026918
Disease: Mycobacterium Infections
Mycobacterium Infections 		0.030 GeneticVariation group BEFREE Moreover, IRF-8⁻/⁻ mice, relying on a common human and mouse genetic mutation linked to susceptibility/severity of mycobacterial diseases, represent a valuable model of acute TB for comparative studies with chronically-infected congenic WT-B6 for dissecting protective and pathological immune reactions. 23717393 2013