IRF8, interferon regulatory factor 8, 3394

N. diseases: 149; N. variants: 20
Disease: Myeloproliferative disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.040 Biomarker group BEFREE Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish. 28626217 2018
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.040 Biomarker group BEFREE Previous research had implicated IRF8 as a tumor suppressor for myeloid neoplasia, and mice lacking IRF8 develop a well-differentiated myeloproliferative neoplasm characterized by expansion of neutrophilic lineage cells. 30266821 2018
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.040 Biomarker group BEFREE ICSBP-deficient mice develop a myeloproliferative disorder characterized by cytokine hypersensitivity and apoptosis resistance. 18195016 2008
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.040 Biomarker group BEFREE Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder. 10648600 2000