IRF8, interferon regulatory factor 8, 3394

N. diseases: 149; N. variants: 20
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE Collectively, our data uncover Irf8 as a roadblock for β-catenin-driven leukemia and imply both factors as targets in combinatorial therapy. 24101380 2013
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 AlteredExpression disease BEFREE The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp). 22262849 2012
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 AlteredExpression disease BEFREE When analyzed in four leukemia mRNA expression data sets, WT1 and IRF8 were anticorrelated. 20237505 2010
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE To investigate this hypothesis, we used chromatin co-immunoprecipitation to identify genes involved the ICSBP-leukemia suppressor effect. 19801548 2009
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 AlteredExpression disease BEFREE Remarkably, the evolution of Alox15 MPD to leukemia is associated with additional regulation of ICSBP on an RNA level, highlighting the potential usefulness of the Alox15 model for understanding the transition of CML to crisis. 17043146 2006
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE Therefore, these studies suggest that leukemia-associated ICSBP deficiency cooperates with leukemia-associated activating mutants of SHP2-PTP to contribute to the proliferative phenotype in myeloid malignancies. 16914719 2006
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia. 16939812 2006