GADL1, glutamate decarboxylase like 1, 339896

N. diseases: 192; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Average ADC values for diffuse midline gliomas were 1.28 × 10<sup>-3</sup>mm<sup>2</sup>/s (95% CI, 1.21-1.34) and 0.86 × 10<sup>-3</sup>mm<sup>2</sup>/s (95% CI, 0.69-1.01) for hemispheric glioblastomas with <i>P</i> < .05. 31694820 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Treatment of GBM with BVZ leads to a decrease of ADC values in areas of pre-treatment T1-CE/FLAIR signal hyperintensity to levels of comparable with normal brain tissue. 29733920 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE The exact significance of ADC maps in GBM has yet to be elaborated. 31229576 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. 29721688 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 GeneticVariation disease BEFREE To investigate the potential to predict prognosis of glioblastoma (GBM) patients by analysis of the broader and lower values in the lower distribution of apparent diffusion coefficient (ADC<sub>L</sub>) (B&L-ADC<sub>L</sub>) values in the ADC histogram. 29274693 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE When minimum ADC was combined with the tumor-to-normal ratio, the continuous net reclassification improvement was 0.43 (95% CI, -0.17-1.04; <i>P</i> = .16) for diagnosing high-grade glioma, and 1.36 (95% CI, 0.79-1.92; <i>P</i> < .001) for diagnosing glioblastoma. 29301781 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE <i>MGMT</i> promoter methylated glioblastoma is likely to show less edema, high ADC, and low perfusion. 30002055 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE The value of whole lesion ADC histogram profiling to differentiate between morphologically indistinguishable ring enhancing lesions-comparison of glioblastomas and brain abscesses. 29719596 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression disease BEFREE Taken together, we found that a high BCAT1 level is correlated with high CBV and a low ADC value as well as the poor prognosis of BCAT1 expression is related to the aggressive nature of GBM. 29255149 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE On the basis of receiver operating characteristic analysis, mean ADC provided the best threshold (area under the curve = 0.83) to distinguish primary CNS lymphoma from glioblastoma, which was not improved with normalized ADC or the addition of perfusion parameters. 27932505 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Here we investigate whether restriction spectrum imaging, an advanced diffusion imaging model, performed after an operation but before radiation therapy, could improve risk stratification in patients with newly diagnosed glioblastoma relative to ADC. 28279985 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Regions of interest analyses for DCE-MRI permeability parameters (transfer constant [Ktrans], rate transfer coefficient [Kep], and volume fraction of extravascular extracellular space [Ve]) and DTI parameters (apparent diffusion coefficient [ADC] and fractional anisotropy [FA]) were performed on the enhancing solid portion of the glioblastoma. 24949678 2014