IFI27, interferon alpha inducible protein 27, 3429

N. diseases: 332; N. variants: 4
Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 AlteredExpression disease BEFREE In addition, TIPE‑2 selectively decreased neuroblastoma Ras viral oncogene and p27 expression in HCC cells. 29568863 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 AlteredExpression disease BEFREE In the presence of ALK<sup>F1174L</sup> signaling, MYCN induces the expression of the ubiquitin ligase SKP2 (S-phase kinase-associated protein 2), which targets p27 for degradation and is also upregulated in high-risk NB. 27707976 2016
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 AlteredExpression disease BEFREE In this regard, we examined the role of the tumor-suppressor gene CDKN1B (also known as p27 and Kip1) and the oncogene ID2 in relationship to CDKN2A expression, MYCN amplification, and neuroblastoma pathogenesis in 17 neuroblastoma cell lines and 129 samples of primary tumors of all stages. 15390183 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 Biomarker disease BEFREE Thus, RA induces both N-myc-dependent and -independent mechanisms to minimize the degradation of p27 and arrest NB cell growth. 12700651 2003
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 Biomarker disease BEFREE Abnormalities, including deletions and point mutations of the p16, p18, and p27 genes, were not observed in this series of neuroblastomas. 8630967 1996