IFI27, interferon alpha inducible protein 27, 3429
N. diseases: 332; N. variants: 4
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.050 | Biomarker | disease | BEFREE | A processing intermediate RSV prefusogenic F has been reported in infected cells, purified F, budded virus, and elicited a strong immune response against p27 in RSV infected young children. | 31416644 | 2019 |
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0.050 | GeneticVariation | disease | BEFREE | Infection with recombinant virus lacking the N-glycosylation site at position N116 (RSV F N116Q) resulted in significant higher neutralizing antibody titers compared to RSV F WT infection, which is surprising since this N-glycan is present in the p27 peptide which is assumed to be absent from the mature F protein in virions. | 31004621 | 2019 |
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0.050 | Biomarker | disease | BEFREE | Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization. | 30110893 | 2018 |
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0.050 | Biomarker | disease | BEFREE | In comparison, RSV/B had 19 aa changes in antigenic sites: I (N = 3), II (N = 1), p27 (N = 9), ø (N = 4), α2α3β3β4(AM14) (N = 1), and MPE8 (N = 1), ranging in frequency from 79-100%. | 28414749 | 2017 |
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0.050 | AlteredExpression | disease | BEFREE | The gene IFI27 is upregulated and the gene CLC is downregulated in whole blood of infants hospitalised with RSV, subtype B, bronchiolitis and is not reported before. | 17166282 | 2006 |