IFI27, interferon alpha inducible protein 27, 3429

N. diseases: 332; N. variants: 4
Disease: Liver regeneration disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.020 Biomarker phenotype BEFREE However, the role of microRNA (miR)‑26a in regulating complex signalling networks involving E3 ubiquitin‑protein ligase Mdm2 (mdm2), p53, p21 and p27 in the process of LR is currently unclear. 31364731 2019
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.020 Biomarker phenotype BEFREE These results identify Dicer production of miR-221 as an essential component of a miRNA-dependent mechanism for suppression of p27 that controls the rate of hepatocyte proliferation after partial hepatectomy.<b>NEW & NOTEWORTHY</b> Our findings demonstrate a direct role for microRNAs in controlling the rate of liver regeneration after injury. 28232457 2017