|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 39 single nucleotide polymorphism loci in 23 genes of the TLR-IFN pathway and four HLA polymorphism loci associated with chronic HBV infection identified by GWAS were selected for genotyping.
|
25469587 |
2015 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For HBeAg-positive patients and HBeAg-negative patients with genotype D infection, PEG-IFN therapy could be terminated early at week 12 or 24 in primary non-responders defined by the Hepatitis B surface antigen stopping rules.
|
24738850 |
2014 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Vitamin D serum levels and receptor genetic polymorphisms are associated with hepatitis B virus and HIV infections and IFN-λ levels.
|
29493287 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since hepatitis B virus (HBV) genotype is an important predictor of response to PEG-IFN, determination of HBV genotype is essential in patients in whom sustained off-treatment response is pursued.
|
19187869 |
2008 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Viral genotype and hepatitis B surface antigen (HBsAg) decline were the most important predictive factor for PEG-IFN response.
|
27017932 |
2016 |
|
Liver Cirrhosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
During follow-up, two patients of the control group and three patients of the IFN group developed cirrhosis, and one of the IFN- treated patients progressed to hepatocellular carcinoma.
|
16012762 |
2005 |
|
Liver Cirrhosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Productive infections have been achieved recently with genotype 2a virus, but cirrhosis and liver cancer are typically associated with genotype 1 HCV, which is more prevalent and relatively resistant to IFN therapy.
|
16461899 |
2006 |
|
Liver Cirrhosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We failed to demonstrate any association between -308 TNF-alpha promoter polymorphisms and response to IFN therapy, which was inversely correlated to liver cirrhosis, pretreatment serum HCV RNA levels and genotype 1b by using multivariate analysis.
|
12834858 |
2003 |
|
Liver Cirrhosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Power and sample size were a priori calculated and 96 consecutive chronic hepatitis C patients (53, genotype 2 and 43, genotype 3) without cirrhosis who were not obese and who achieved a RVR to therapy with peg-IFN-α-2a and ribavirin were enrolled.
|
22497814 |
2012 |
|
Liver Cirrhosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a pilot study of long-term treatment, 42 such patients were randomly assigned to 6 million units of interferon alfa 2b (IFN-alpha2b) three times per week for 24 consecutive months (n = 21, 4 with cirrhosis) or to no therapy (n = 21, 3 with cirrhosis).
|
9398007 |
1997 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous losses were found in 8/14 (57%) fresh melanoma biopsy DNAs with the smallest region of overlap (SRO) being between IFNA and D9S169.
|
8108124 |
1994 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that CSF-470 vaccine plus BCG plus GM-CSF can significantly prolong, with lower toxicity, the DMFS of high-risk CM pts with respect to medium-dose IFN-α2b.
|
28620382 |
2017 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data confirm the existence of a melanoma susceptibility gene on 9p and indicate that this locus most probably lies outside of the IFNA-D9S126 interval.
|
8213823 |
1993 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Seventeen SN tested for loss of heterozygosity (LOH) at 9p and 10q regions, known to be frequently deleted in melanoma, showed LOH at the 9p loci D9S942 and IFNA.
|
17518771 |
2007 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Persistence of hepatocellular carcinoma risk in hepatitis C patients with a response to IFN and cirrhosis regression.
|
29377616 |
2018 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
During follow-up, two patients of the control group and three patients of the IFN group developed cirrhosis, and one of the IFN- treated patients progressed to hepatocellular carcinoma.
|
16012762 |
2005 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the rs8099917 single-nucleotide polymorphism in 351 hepatitis C-associated HCC patients without history of IFN-based treatment, and correlated the age at onset of HCC in patients with each genotype.
|
23689989 |
2014 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There has been some debate if IFN-free therapy with direct-acting antivirals alters the risk for HCC.
|
29205405 |
2018 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IFNA1- rs1831583 and IFNA2- rs649053 are associated with the development of HCC.
|
29080269 |
2018 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, we failed to uncover any significant association between other polymorphisms in genes of IL-12 signaling pathway and HCC risk, including <i>IL18</i>-rs1946518 and -rs187238, <i>IFN-γ</i>-rs2430561, <i>IL12A</i>-rs568408, <i>IL12B</i>-rs3212227 and <i>STAT4</i>-rs7574865.
|
30310516 |
2018 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PD-L1 positive HCC was observed in 6 cases of the IFN group and 4 cases of the DAA group.
|
31423211 |
2019 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In patients with previous HCC treated with curative therapies, HCC recurrence occurred in two (25%) out of eight patients treated with IFN-based regimens and four (21%) out of 19 treated with DAA-IFN-free regimens (P = 1.0).
|
29596108 |
2018 |
|
Fibrosis, Liver
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
To assess the influence of liver fibrosis on the outcome of anti-HCV therapy, all patients with genotype 3a hepatitis C who were naive to IFN-based therapies, and received RBV combined with standard IFN or pegylated IFN-(alpha2b (peg-IFN-alpha2b) as standard of care for their disease, were investigated at our centre.
|
17310824 |
2006 |
|
Fibrosis, Liver
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We examined the relationship between IFN-λ genotypes and significant liver fibrosis in HIV-HCV coinfection.
|
26984148 |
2016 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
In this study, we demonstrate that an As(2)O(3) and IFN-α combination, known to trigger Tax proteolysis, cures Tax-driven ATL in mice.
|
21135137 |
2010 |