melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Binding studies indicated the presence of 2,980 +/- 170 receptors per cell, each with an apparent Kd of (8.4 +/- 1.3) X 10(-11) M. Results from competitive binding studies suggested that Hs294T cells possess at least two types of IFN receptors: one which binds IFN-alpha A and IFN-beta 1 and another to which IFN-gamma binds.
|
6319748 |
1984 |
Carcinoma of bladder
|
0.070 |
Biomarker
|
disease |
BEFREE |
Mouse IFN inhibited the development of transformed foci in NIH 3T3 cultures transfected with the viral Ha-MuSV(ras) and Mo-MuSV(mos) oncogenes, or with the human bladder carcinoma ras EJ/T24 DNA.
|
3970704 |
1985 |
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MNC of patients with SLE have defects in the IL-2 signal transduction which is required for production of gamma-IFN.
|
2429672 |
1986 |
Systemic Scleroderma
|
0.090 |
Biomarker
|
disease |
BEFREE |
These findings indicate that rec gamma-IFN can modulate the excessive collagen biosynthesis characteristic of PSS fibroblasts and that this effect can be explained largely by the gamma-IFN-mediated decrease in specific collagen mRNAs.
|
3091039 |
1986 |
Hepatitis A
|
0.090 |
Biomarker
|
disease |
BEFREE |
In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK).
|
2461050 |
1988 |
Neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
The potent effect of IFN suggests a role for these modulators in NB behaviour in vivo.
|
3243386 |
1988 |
Central neuroblastoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The potent effect of IFN suggests a role for these modulators in NB behaviour in vivo.
|
3243386 |
1988 |
Childhood Neuroblastoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The potent effect of IFN suggests a role for these modulators in NB behaviour in vivo.
|
3243386 |
1988 |
Hepatitis
|
0.060 |
Biomarker
|
group |
BEFREE |
In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK).
|
2461050 |
1988 |
Fanconi Anemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia.
|
2484652 |
1988 |
Hairy Cell Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The number of IFN-gamma receptors on our patient's MNCs was four times higher than the number of IFN-alpha receptors and was similar to the number of IFN-alpha receptors on MNCs from HCL patients responsive to IFN-alpha.
|
2846090 |
1988 |
Constitutional aplastic anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia.
|
2484652 |
1988 |
Myeloid Leukemia, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Such findings reveal that the effect of alpha-2-IFN in CML patients can be unexpectedly prolonged after discontinuance of treatment.
|
2792317 |
1989 |
Thrombocytosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis.
|
2757963 |
1989 |
CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis.
|
2757963 |
1989 |
CAMPOMELIC DYSPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis.
|
2757963 |
1989 |
Coronary Microvascular Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis.
|
2757963 |
1989 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the level of Mx-homologous protein induced during IFN therapy is not a predictive marker for an antitumor response in malignant melanoma.
|
1701809 |
1990 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The unique de novo and IFN-modified antigenic phenotype of cultures derived from different patients indicates that the antigenic phenotype displayed by melanoma cultures grown in vitro is genetically determined.
|
2118485 |
1990 |
Myeloid Leukemia, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon-alpha (1,000 U/ml) reduced the effects of the CML myeloid cell cytoplasmic protein on the electrophoretic mobility of nuclear protein-DNA complexes.
|
2243138 |
1990 |
Hepatitis B, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a randomized controlled trial of recombinant alpha-2a interferon for chronic hepatitis B, interferon antibodies developed in 21 (39%) of 54 Chinese adults who received IFN.
|
2258142 |
1990 |
Coinfection
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
HIV-1 infection did not stimulate constitutive production of endogenous IFN-alpha 1/alpha 2 or IFN-beta genes, although induction of IFN RNA was observed following coinfection with the paramyxovirus Sendai.
|
1699354 |
1990 |
Acute lymphocytic leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Scanning densitometry and restriction fragment length polymorphism analysis were used to study the alpha-, beta-, gamma-, and omega-interferon (IFN) genes in malignant cells from 11 children with acute lymphocytic leukemia and in one cell line of T-cell origin.
|
1701354 |
1990 |
Vesicular Stomatitis
|
0.050 |
Biomarker
|
disease |
BEFREE |
The antiviral function of IFN, as tested by inhibition by vesicular stomatitis virus (VSV) infection, and the IFN-receptor binding are not suppressed.
|
2153074 |
1990 |
Cytomegalovirus Infections
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Secretion by peripheral blood mononuclear cells is increased if they are cultured with host fibroblasts infected with CMV in vitro and the levels of gamma IFN and TNF produced are within the range that protects fresh fibroblasts from CMV infection.
|
2168224 |
1990 |