Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
The gist of current study is to assess the role of IBD-associated autophagy gene IRGM on AS susceptibility in a Chinese Han population.
|
28031552 |
2017 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
We analyzed known autophagic loci (IRGM, ULK1 and AMBRA1) previously described as associated with inflammatory bowel diseases or with other autoimmune and/or inflammatory disorders in a sample of Italian inflammatory bowel diseases patients in order to confirm their possible involvement and relative contribution in the disease.
|
26066377 |
2015 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
CTD_human |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This study examined the association of IRGM mutations with ulcerative colitis and Crohn's disease in Indian patients with inflammatory bowel disease.
|
25191865 |
2014 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
IRGM variants and susceptibility to inflammatory bowel disease in the German population.
|
23365659 |
2013 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in immunity-related GTPase family M (IRGM) gene may be associated with inflammatory bowel disease (IBD) by affecting autophagy.
|
24232856 |
2013 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population.
|
22508677 |
2013 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
The discovery that several genes linked to IBD modulate microbial recognition and innate immune pathways, such as nucleotide oligomerization domain 2 (Nod2), and genes that mediate autophagy (ie, ATG16L1, IRGM), has highlighted the critical role of host-microbe interactions in controlling intestinal immune homeostasis.
|
22955361 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We analysed five variants (rs10758669 within JAK2, rs744166 within STAT3, rs4958847, rs11747270 and rs13361189 within IRGM) in adult German inflammatory bowel disease patients (CD, n = 464; ulcerative colitis (UC), n = 292) and matched healthy controls (n = 508).
|
22065112 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
The discovery of the autophagy genes ATG16L1 and IRGM as risk factors for Crohn's disease turned autophagy into the spotlight in inflammatory bowel disease (IBD).
|
21252204 |
2011 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
We reexamined these findings as well as the role of another inflammatory bowel disease (IBD) susceptibility gene (immunity-related GTPase family, M [IRGM]) on transplantation outcomes in 390 US patients and their matched unrelated donors, accrued between 1995 and 2004.
|
20177049 |
2010 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Based on this idea, NKX2-3, ATG16L1, and IRGM which are well-established inflammatory bowel disease risk factors, could be new celiac disease (CD) candidate genes.
|
19683022 |
2009 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.
|
19491842 |
2009 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Genome scans have robustly identified 11 susceptibility genes and loci and highlighted a number of new, previously unsuspected pathways as playing an important role in IBD pathogenesis-including the IL23 pathway in IBD overall and specific aspects of innate immunity (particularly NOD2 and the autophagy genes ATG16L1 and IRGM) in CD.
|
18753178 |
2008 |