Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Through the study of patients and mouse models, it has emerged that Crohn's disease is driven by the production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma), whereas ulcerative colitis is probably driven by the production of IL-13.
|
12876555 |
2003 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these results suggest a potential role for ZIP8 in intestinal inflammation, induced by IFNγ in the intestinal epithelial compartment, and that perturbations in negative regulation of NF-κB by ZIP8 A391T may contribute to CD pathogenesis.
|
31151823 |
2019 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
BT-11 significantly decreases interferon gamma positive (IFNγ+) and tumor necrosis factor alpha positive (TNFα+) cluster of differentiation 4 positive (CD4+) T cells and increases forkhead box P3 positive (FOXP3+) CD4+ T cells in colonic lamina propria mononuclear cells from patients with CD and patients with UC at concentrations of 0.01 µM when treated ex vivo.
|
31077582 |
2020 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified decreased expression of RNASET2 as a component of TL1A-mediated increase in production of IFNG and as a potential biomarker for patients with severe CD.
|
28400196 |
2017 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated levels of the pro-inflammatory cytokine, interferon-gamma (IFNgamma), are believed to be prominently involved in the pathogenesis of Crohn disease.
|
19654324 |
2009 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.
|
18497880 |
2008 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
A sensitive reverse haemolytic plaque assay to detect lymphokine-secreting T cells, and Northern blot analysis to detect expression of lymphokine messenger RNA (mRNA) were used to study interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) production in the mucosa of children with Crohn's disease or ulcerative colitis (UC), and in histologically normal mucosa from patients without inflammatory bowel disease.
|
8436398 |
1993 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.
|
25171510 |
2014 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Granzyme B mRNA levels correlated with interferon gamma mRNA levels in Crohn's disease.
|
10657017 |
2000 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, lncRNA ANRIL expression was negatively associated with Crohn's disease activity index (P = 0.002), C-reactive protein (P < 0.001) and erythrocyte sedimentation rate (P = 0.001), and associated with tumor necrosis factor-α (P < 0.001), IL-17 (P < 0.001) and interferon gamma messenger RNA levels (P = 0.004) but positively associated with IL-10 messenger RNA level (P = 0.002).
|
30665494 |
2019 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that polymorphisms in the Toll-like receptor (TLR), the apoptosis, the IL-23/IL-17 and the interferon gamma (IFNG) pathways are associated with risk of both CD and UC.
|
26698117 |
2015 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease.
|
23176201 |
2013 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease.
|
23575333 |
2013 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects.
|
26072972 |
2015 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Crohn's disease (CD) susceptibility gene, protein tyrosine phosphatase N2 (PTPN2), regulates interferon γ (IFNγ)-induced signalling and epithelial barrier function in T₈₄ intestinal epithelial cells (IECs).
|
21115548 |
2011 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IFN-γ was associated with the disease activity in UC, but did not reach significant level in CD.
|
21945121 |
2011 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The stimulatory effects of these cytokines on naive T cells in addition to a strongly synergistic action with IL-12 to trigger interferon-gamma production may contribute to the perpetuation of the inflammatory process in patients with CD.
|
15674109 |
2005 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that the frequency of IFN-γ- and IL-17-expressing CD4 T cells was significantly higher after stimulation with CD bacteria than with non-CD bacteria, while the frequency of IL-4- and IL-10-expressing CD4 T cells was significantly decreased after stimulation with CD bacteria.
|
29031634 |
2017 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The pathway modulates interferon gamma, which induces the JAK/STAT pathway that is involved in Crohn's disease.
|
27622767 |
2016 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intestinal and mesenteric lymph node samples from 9 children who had undergone ileal resection for CD were examined for the presence of epithelioid-giant cell granulomas (EGCG) and Rantes and IFN-gamma messenger RNA (mRNA).
|
9327364 |
1997 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides gene-level CD association P-values, association with AI diseases was the strongest predictor, highlighting generalized mechanisms of inflammation, and the interferon-γ pathway particularly.
|
25935003 |
2015 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
It has recently been suggested that Crohn's Disease (CD) is associated with an exaggerated T helper 1 cytokine response as manifest by increased production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma).
|
11515847 |
2001 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied markers in the genes for NRAMP1 and two mutations in the interferon-gamma receptor in relation to inflammatory bowel disease (IBD) in the following groups: 270 healthy individuals, 74 patients with Crohn's disease, 72 patients with ulcerative colitis, and 40 patients with primary sclerosing cholangitis.
|
10207725 |
1999 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quantitative gene expression analysis, by real-time PCR, of IL-32, IL-1β, IL-10, TNF-α and IFN-γ was performed on ileal biopsies of 15 AS and 15 Crohn's disease (CD) patients and 10 healthy subjects (HSs).
|
22847681 |
2012 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
|
21829567 |
2011 |