|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
A sensitive reverse haemolytic plaque assay to detect lymphokine-secreting T cells, and Northern blot analysis to detect expression of lymphokine messenger RNA (mRNA) were used to study interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) production in the mucosa of children with Crohn's disease or ulcerative colitis (UC), and in histologically normal mucosa from patients without inflammatory bowel disease.
|
8436398 |
1993 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intestinal and mesenteric lymph node samples from 9 children who had undergone ileal resection for CD were examined for the presence of epithelioid-giant cell granulomas (EGCG) and Rantes and IFN-gamma messenger RNA (mRNA).
|
9327364 |
1997 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The early ileal lesions of patients with CD were associated with a significant increase of IL-4 mRNA and a decrease of IFN-gamma mRNA compared with the normal mucosa of patients with CD or controls.
|
9207269 |
1997 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied markers in the genes for NRAMP1 and two mutations in the interferon-gamma receptor in relation to inflammatory bowel disease (IBD) in the following groups: 270 healthy individuals, 74 patients with Crohn's disease, 72 patients with ulcerative colitis, and 40 patients with primary sclerosing cholangitis.
|
10207725 |
1999 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Granzyme B mRNA levels correlated with interferon gamma mRNA levels in Crohn's disease.
|
10657017 |
2000 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
It has recently been suggested that Crohn's Disease (CD) is associated with an exaggerated T helper 1 cytokine response as manifest by increased production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma).
|
11515847 |
2001 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Through the study of patients and mouse models, it has emerged that Crohn's disease is driven by the production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma), whereas ulcerative colitis is probably driven by the production of IL-13.
|
12876555 |
2003 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The stimulatory effects of these cytokines on naive T cells in addition to a strongly synergistic action with IL-12 to trigger interferon-gamma production may contribute to the perpetuation of the inflammatory process in patients with CD.
|
15674109 |
2005 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
An increased expression of interleukin-18 (IL-18), a proinflammatory cytokine inducing interferon-gamma, has been found in Crohn's disease (CD).
|
16306764 |
2005 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-2 and IFN-gamma were downregulated in PBMNC from CD and UC.
|
15827446 |
2005 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.
|
18497880 |
2008 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles.
|
18287963 |
2008 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The reason for the decreased frequency of an in vitro T(H)-cell IFNgamma response toward E. coli proteins in peripheral blood of CD and AS patients, e.g., increased suppression needs to be clarified.
|
19079222 |
2008 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated levels of the pro-inflammatory cytokine, interferon-gamma (IFNgamma), are believed to be prominently involved in the pathogenesis of Crohn disease.
|
19654324 |
2009 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the circulating IFN-γ and IL-12 production in 2 groups of Algerian patients with IBD (Crohn's disease and ulcerative colitis).
|
20626296 |
2010 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Crohn's disease (CD) susceptibility gene, protein tyrosine phosphatase N2 (PTPN2), regulates interferon γ (IFNγ)-induced signalling and epithelial barrier function in T₈₄ intestinal epithelial cells (IECs).
|
21115548 |
2011 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IFN-γ was associated with the disease activity in UC, but did not reach significant level in CD.
|
21945121 |
2011 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
|
21829567 |
2011 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quantitative gene expression analysis, by real-time PCR, of IL-32, IL-1β, IL-10, TNF-α and IFN-γ was performed on ileal biopsies of 15 AS and 15 Crohn's disease (CD) patients and 10 healthy subjects (HSs).
|
22847681 |
2012 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated IL-17A levels were positively correlated with IFN-γ in both inflammatory CD and UC but IL-17A and IFN-γ were correlated with IL-23p19 in CD ileum only.
|
21994045 |
2012 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
IFN-γ is known not only to play an important role in the pathogenesis of Crohn's disease (CD), but also to increase permeability of the intestinal epithelial barrier.
|
22671596 |
2012 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease.
|
23176201 |
2013 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease.
|
23575333 |
2013 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The percentages of circulating Th1 (CD3+CD8-IFN-γ+) and Tc1 (CD3+CD8+IFN-γ+) cells were also higher in patients with active UC when compared with the percentages in patients with inactive UC and normal controls, although levels were lower than that in CD.
|
23446770 |
2013 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.
|
25171510 |
2014 |