Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
BT-11 significantly decreases interferon gamma positive (IFNγ+) and tumor necrosis factor alpha positive (TNFα+) cluster of differentiation 4 positive (CD4+) T cells and increases forkhead box P3 positive (FOXP3+) CD4+ T cells in colonic lamina propria mononuclear cells from patients with CD and patients with UC at concentrations of 0.01 µM when treated ex vivo.
|
31077582 |
2020 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these results suggest a potential role for ZIP8 in intestinal inflammation, induced by IFNγ in the intestinal epithelial compartment, and that perturbations in negative regulation of NF-κB by ZIP8 A391T may contribute to CD pathogenesis.
|
31151823 |
2019 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, lncRNA ANRIL expression was negatively associated with Crohn's disease activity index (P = 0.002), C-reactive protein (P < 0.001) and erythrocyte sedimentation rate (P = 0.001), and associated with tumor necrosis factor-α (P < 0.001), IL-17 (P < 0.001) and interferon gamma messenger RNA levels (P = 0.004) but positively associated with IL-10 messenger RNA level (P = 0.002).
|
30665494 |
2019 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The A allele of IFN-γ +874 polymorphism was overrepresented in the whole population of patients with IBD (OR 1.63; 95% CI 1.08-2.47; p = 0.020) and as well in the subpopulation of patients with CD (OR 2.14; 95% CI 1.26-3.63; p = 0.004), but not in UC.
|
30134230 |
2019 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using a candidate gene approach, 21 functional single-nucleotide polymorphisms (SNPs) in 14 genes in the Toll-like receptors, the inflammasome and the IFNG pathways were assessed in 482 and 256 prior anti-TNF naïve Danish patients with CD and UC, respectively.
|
28139755 |
2018 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the multiplex assay, serum concentrations (pg/mL) of IL-4 (9.6 ± 1.5 vs. 12.7 ± 3.0), IL-21 (14.9 ± 1.5 vs. 26.4 ± 9.1), IL-33 (14.3 ± 0.9 vs. 19.1 ± 5.3), and IFN-γ (15.2 ± 5.9 vs. 50.2 ± 42.4) were significantly lower in Crohn's disease than those in the control group.
|
30584414 |
2018 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified decreased expression of RNASET2 as a component of TL1A-mediated increase in production of IFNG and as a potential biomarker for patients with severe CD.
|
28400196 |
2017 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that the frequency of IFN-γ- and IL-17-expressing CD4 T cells was significantly higher after stimulation with CD bacteria than with non-CD bacteria, while the frequency of IL-4- and IL-10-expressing CD4 T cells was significantly decreased after stimulation with CD bacteria.
|
29031634 |
2017 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overproduction of pro-inflammatory cytokine Interferon-γ (IFN-γ) induces the excessive apoptosis of IECs and is involved in CD development.
|
28476379 |
2017 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regarding miR-125b, no association with CRP, CDAI, IL-17, TNF-α, or IFN-γ was found in A-CD or in R-CD patients. miR-125a levels gradually increased in A-CD patients who achieved clinical remission (<i>P</i> = 0.009) after 3-mo treatment, whereas they remained unchanged among patients who failed to achieve remission.
|
29209130 |
2017 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The pathway modulates interferon gamma, which induces the JAK/STAT pathway that is involved in Crohn's disease.
|
27622767 |
2016 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that polymorphisms in the Toll-like receptor (TLR), the apoptosis, the IL-23/IL-17 and the interferon gamma (IFNG) pathways are associated with risk of both CD and UC.
|
26698117 |
2015 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects.
|
26072972 |
2015 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides gene-level CD association P-values, association with AI diseases was the strongest predictor, highlighting generalized mechanisms of inflammation, and the interferon-γ pathway particularly.
|
25935003 |
2015 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data are in concordance with the fact that CD has been shown to be associated with a Th1 T-cell-mediated inflammation model and high IL12/IFNγ production at histological affected sites.
|
25359546 |
2015 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate no quantitative difference in phenotype, in vitro growth kinetics and molecular signatures to IFNγ between MSCs derived from CD and healthy individuals.
|
25899824 |
2015 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.
|
25171510 |
2014 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Basal levels of P2X7-R mRNA were higher in CD inflamed mucosa compared with noninflamed CD and controls and were upregulated after interferon-γ in controls.
|
24412990 |
2014 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease.
|
23176201 |
2013 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease.
|
23575333 |
2013 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The percentages of circulating Th1 (CD3+CD8-IFN-γ+) and Tc1 (CD3+CD8+IFN-γ+) cells were also higher in patients with active UC when compared with the percentages in patients with inactive UC and normal controls, although levels were lower than that in CD.
|
23446770 |
2013 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quantitative gene expression analysis, by real-time PCR, of IL-32, IL-1β, IL-10, TNF-α and IFN-γ was performed on ileal biopsies of 15 AS and 15 Crohn's disease (CD) patients and 10 healthy subjects (HSs).
|
22847681 |
2012 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated IL-17A levels were positively correlated with IFN-γ in both inflammatory CD and UC but IL-17A and IFN-γ were correlated with IL-23p19 in CD ileum only.
|
21994045 |
2012 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
IFN-γ is known not only to play an important role in the pathogenesis of Crohn's disease (CD), but also to increase permeability of the intestinal epithelial barrier.
|
22671596 |
2012 |