IFNG, interferon gamma, 3458
N. diseases: 1519; N. variants: 11
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | AlteredExpression | disease | BEFREE | In contrast, Lr-pulsed DC/CD4<sup>+</sup> T-cell co-cultures expressed low IL-10, high IL-12p70 and IFN-γ levels and declined Treg population; this responsiveness pattern was not changed by Hp. | 31328382 | 2019 |
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0.100 | Biomarker | disease | BEFREE | Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response. | 29273450 | 2018 |
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0.100 | AlteredExpression | disease | BEFREE | Gastric expression of IL-17A and IFNγ in Helicobacter pylori infected individuals is related to symptoms. | 28683359 | 2017 |
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0.100 | Biomarker | disease | BEFREE | Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon- γ Signaling. | 25945338 | 2015 |
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0.100 | AlteredExpression | disease | BEFREE | Hp GE-driven enhancement of lymphocyte cytotoxic activity was associated with the expansion of CD3(-)CD56(+)CD25(+) NK cells and the up-regulation of IFN-γ and/or IL-2 synthesis, up to the higher level in Hp(-) than in Hp(+), while Hp LPS-mediated decrease in lymphocyte cytotoxicity was accompanied by the lack of CD3(-)CD56(+)CD25(+) NK propagation, the inhibition of pro-inflammatory cytokine expression and intense expansion of IL-10-producing NK cells. | 24448078 | 2015 |
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0.100 | Biomarker | disease | BEFREE | A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease. | 23067142 | 2013 |
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0.100 | Biomarker | disease | BEFREE | Virulent Helicobacter pylori strains that specifically activate signaling in epithelial cells via the innate immune molecule, nucleotide oligomerization domain 1 (NOD1), are more frequently associated with IFN-γ-dependent inflammation and with severe clinical outcomes (i.e., gastric cancer and peptic ulceration). | 23460743 | 2013 |
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0.100 | Biomarker | disease | BEFREE | Interferon-gamma secretion is induced in IL-12 stimulated human NK cells by recognition of Helicobacter pylori or TLR2 ligands. | 20130107 | 2011 |
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0.100 | Biomarker | disease | BEFREE | In the early stage, initial response to self-antigens (LF, CA-II, CA-IV, PSTI, or α-fodrin) or molecular mimicry (Helicobacter pylori) is induced by decreased naive regulatory T cells (Tregs), and Th1 cells release proinflammatory cytokines (IFN-γ, IL-1b, IL-2, and TNF-α). | 20862490 | 2010 |
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0.100 | Biomarker | disease | BEFREE | Blocking Smad7 with antisense oligonucleotides restored TGF-beta 1 signaling in biopsy specimens from Hp-infected patients and concomitantly reduced interferon-gamma and T-bet. | 14988821 | 2004 |
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0.100 | Biomarker | disease | BEFREE | Up-regulation of inducible nitric oxide synthase and nitric oxide in Helicobacter pylori-infected human gastric epithelial cells: possible role of interferon-gamma in polarized nitric oxide secretion. | 11966872 | 2002 |
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0.100 | Biomarker | disease | BEFREE | Upregulation of mucosal soluble fas ligand and interferon-gamma may be involved in ulcerogenesis in patients with Helicobacter pylori-positive gastric ulcer. | 12059049 | 2002 |