Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies indicated that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and IFNG receptor 1 (IFNGR1) may be involved in the pathogenesis of pulmonary tuberculosis (PTB) in different populations.
|
31687049 |
2019 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allele T frequencies of IFNγR1 -56 C/T promoter region in patients with pulmonary TB (PTB) or extrapulmonary TB (EPTB) were significantly greater than allele C. The -56 TT motif of IFNγR1 is associated with both forms of TB (p<0.05).
|
27941164 |
2016 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusions, our study revealed a significant association of IFN-γR1 and P2X7 genes polymorphisms with risk of developing TB in Iranian population.
|
27020872 |
2016 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims to explore the single and joint effect of genetic polymorphisms of interferon-gamma (IFNG) and its receptor (IFNGR1) in association with the pulmonary tuberculosis in a Chinese Han population.
|
24680779 |
2014 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.
|
19575238 |
2009 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The IFN-gamma and IFN-gammaR1 gene polymorphisms do not appear to be responsible for host susceptibility to pulmonary TB in the Korean population.
|
17986123 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have indicated that IFN-gamma and IFN-gamma receptor 1 (IFN-gammaR1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis.
|
17023216 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IFN-gamma and IFN-gammaR1 gene polymorphisms do not appear to be responsible for host susceptibility to pulmonary TB in the Korean population.
|
17986123 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IFNGR1 allele CA(12) (p=0.004) and genotype CA(12)/CA(12) (p=0.01; OR 0.5) were associated with protection from pulmonary tuberculosis.
|
17392024 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Lack of association between interferon-gamma receptor-1 polymorphism and pulmonary TB in Iranian population sample.
|
16233916 |
2006 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between interferon-gamma receptor-1 polymorphism and pulmonary TB in Iranian population sample.
|
16233916 |
2006 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data represent an important negative finding and suggest that, while IFNGR1 is implicated in rare Mendelian susceptibility to mycobacterial disease, the common variants studied here do not have a major influence on susceptibility to pulmonary TB in The Gambian population.
|
15047947 |
2004 |