Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer. 30370603 2019
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE MicroRNA-940 restricts the expression of metastasis-associated gene MACC1 and enhances the antitumor effect of Anlotinib on colorectal cancer. 31114229 2019
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Our results establish MACC1 as a transcriptional target of Wnt/β-catenin signaling and suggest that DBC1 plays a key role in colorectal cancer progression through Wnt/β-catenin-MACC1 signaling axis. 30082743 2018
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE miR-433 reduces cell viability and promotes cell apoptosis by regulating MACC1 in colorectal cancer. 28123526 2017
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. 28498456 2017
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE The MACC1-SPON2 axis: a new biomarker and therapeutic target in colorectal cancer. 27669439 2017
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer. 28943898 2017
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Several biomarkers and mutations of aggressive tumor behavior have been defined such as metastasis-associated in colon cancer 1 (MACC1) that was associated with metastasis in colorectal cancer patients. 27439755 2016
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer. 27462788 2016
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MicroRNA target for MACC1 and CYR61 to inhibit tumor growth in mice with colorectal cancer. 27492459 2016
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Therefore, we conducted this meta-analysis to investigate the effect of MACC1 overexpression on clinicopathological features and survival outcomes in colorectal cancer. 27542234 2016
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MACC1 Induces Tumor Progression in Transgenic Mice and Colorectal Cancer Patients via Increased Pluripotency Markers Nanog and Oct4. 26758557 2016
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and colorectal cancer. 25738887 2015
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling pathway. 25003996 2014
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancer. 23800415 2013
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MACC1, a new easily detectable biomarker in cancer, is an independent prognostic factor of recurrence after liver resection of colorectal cancer metastasis. 23665971 2013
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Stepwise elevation of MACC1 expression in key points of colorectal cancer development suggests that MACC1 may contribute to cancer initiation and early invasive growth. 24124150 2013
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer. 22838389 2012
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. 23166620 2012
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. 22533346 2012
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE Bioinformatic analysis of putative MACC1 targets identified elements besides Met, whose overexpression cosegregated with aggressive forms of colorectal cancer. 21447729 2011