|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i> functional assays demonstrated that targeting IGF-IR and EGFR didn't affect osteosarcoma cell viability, but inhibited ligand-activated intracellular signaling and cell migratory capacity.
|
28744395 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-1R is an independent prognostic marker for osteosarcoma patients and increased expression of this molecular is correlated with metastasis of osteosarcoma.
|
21866554 |
2012 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro.
|
8052269 |
1994 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor-I may regulate osteosarcoma and the Ewing's family of tumors (primitive neuroectodermal tumors).
|
8054516 |
1994 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells.
|
8281940 |
1993 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of extracellular signal-regulated kinases 1 and 2 by insulin-like growth factor I in human osteosarcoma MG-63 cells.
|
10226783 |
1999 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional studies are needed to determine how IGF-1/IGF-1R interactions contribute to the malignant phenotype of OS.
|
15095405 |
2004 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these results support the conclusions that in MG-63 cells (i) transcriptional rather post-transcriptional mechanisms are involved in the IGF-I-induced increase of IGFBP-3; (ii) the abundance of GH-R is very low at the plasma membrane level; (iii) the dowstream GH-signaling cascade is fully functional in this human osteosarcoma cell line; and (iv) the endogenous IGFBP-3 gene is not responsive to hGH in human MG-63 osteosarcoma cells.
|
11325513 |
2001 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that marked reduction in serum IGF-I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma.
|
19132750 |
2009 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evidence for modulation of osteocalcin containing gamma-carboxyglutamic acid residues synthesis by insulin-like growth factor-I and vitamin K2 in human osteosarcoma cell line MG-63.
|
9578515 |
1998 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we also observed that suppression of IGF-1R could reduce the invasiveness of osteosarcoma cells and enhance their radiosensitivity.
|
19229591 |
2009 |
|
Childhood Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic Polymorphisms of Insulin-Like Growth Factor 1 Are Associated with Osteosarcoma Risk and Prognosis.
|
29232358 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Growth factors (EGF and IGF-1) and mechanical strain had additive effects on the induction of TN-C mRNA expression in OS.
|
24063281 |
2013 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.
|
27931832 |
2016 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, neither Ea nor Eb IGF-I mRNA could be detected under basal conditions or after stimulation with growth hormone in normal hOB cells and two human osteosarcoma cell lines with osteoblastic properties, SaOS-2 and MG-63.
|
8123049 |
1994 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we report a novel mechanism where biglycan through a LRP6/β-catenin/IGF-IR signaling axis enhances osteosarcoma cell growth.
|
30406034 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, our group developed a novel quinazoline derivative, 6-fluoro‑2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline (HMJ‑30), in order to disrupt IGF‑1R signaling and tumor invasiveness in osteosarcoma U‑2 OS cells.
|
29568964 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma.
|
31542501 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, insulin‑like growth factor 1 receptor (IGF‑1R) was characterized as direct target gene of miR‑939 in OS.
|
31545400 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-133a suppresses osteosarcoma progression and metastasis by targeting IGF-1R in human osteosarcoma cells, providing a novel candidate prognostic factor and a potential anti-metastasis therapeutic target in osteosarcoma.
|
26845446 |
2016 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NNT-As1 functions as a cancer-promoting lncRNA by downregulating miR-320a, thus increasing the protein expression level of beta-catenin, RUNX2 and IGF-1R as well as activation of Akt in osteosarcoma.
|
30489194 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nuclear IRS-1 was also detected by cells expressing the SV40 T-antigen, v-Src, in immortalized fibroblasts stimulated with IGF-I, in hepatocytes, 32D cells, and in an osteosarcoma cell line.
|
22454254 |
2012 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our object was to determine whether LTC suppresses MG63 cell proliferation, migration, and invasion, and whether type-1 insulin-like growth factor receptor (IGF-1R) is one of the targets in LTC suppressing osteosarcoma.
|
28844074 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of IGF-I occurs in tumors diagnosed in childhood (osteosarcoma, Wilms tumor, neuroblastoma, etc.) and in adults (breast, ovaries, colon and prostate cancer).
|
17166755 |
2007 |
|
Childhood Osteosarcoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.
|
9492043 |
1998 |