Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review article focused on the role of IGF-1/IGF-1R in OS progression and therapeutic aspects of OS targeting IGF-1.
|
30217668 |
2019 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NNT-As1 functions as a cancer-promoting lncRNA by downregulating miR-320a, thus increasing the protein expression level of beta-catenin, RUNX2 and IGF-1R as well as activation of Akt in osteosarcoma.
|
30489194 |
2019 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, insulin‑like growth factor 1 receptor (IGF‑1R) was characterized as direct target gene of miR‑939 in OS.
|
31545400 |
2019 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma.
|
31542501 |
2019 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we report a novel mechanism where biglycan through a LRP6/β-catenin/IGF-IR signaling axis enhances osteosarcoma cell growth.
|
30406034 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, our group developed a novel quinazoline derivative, 6-fluoro‑2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline (HMJ‑30), in order to disrupt IGF‑1R signaling and tumor invasiveness in osteosarcoma U‑2 OS cells.
|
29568964 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i> functional assays demonstrated that targeting IGF-IR and EGFR didn't affect osteosarcoma cell viability, but inhibited ligand-activated intracellular signaling and cell migratory capacity.
|
28744395 |
2017 |
Childhood Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic Polymorphisms of Insulin-Like Growth Factor 1 Are Associated with Osteosarcoma Risk and Prognosis.
|
29232358 |
2017 |
Childhood Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the carboxyl-terminal of the IGF-1Ec variant (hEc; 24aa) has been associated with osteosarcoma and prostate cancer.
|
28551627 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our object was to determine whether LTC suppresses MG63 cell proliferation, migration, and invasion, and whether type-1 insulin-like growth factor receptor (IGF-1R) is one of the targets in LTC suppressing osteosarcoma.
|
28844074 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This wellpreserved pattern suggests that the alterations in the signaling axes of IGF-1 and TGF-b, in concert with cell cycle regulators, may be an important pathogenic basis of osteosarcoma.
|
26463566 |
2016 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggests that IGF1-3'UTR functions as a ceRNA in promoting angiogenesis by sponging miR-29s in osteosarcoma.
|
26759259 |
2016 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.
|
27931832 |
2016 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-133a suppresses osteosarcoma progression and metastasis by targeting IGF-1R in human osteosarcoma cells, providing a novel candidate prognostic factor and a potential anti-metastasis therapeutic target in osteosarcoma.
|
26845446 |
2016 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrated that transfection of wild-type p53 increases chemosensitivity either through inhibiting IGF-1r or through increasing the expression of pro-apoptotic proteins p21 and Bax in human MDR osteosarcoma cell lines.
|
26698867 |
2016 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Growth factors (EGF and IGF-1) and mechanical strain had additive effects on the induction of TN-C mRNA expression in OS.
|
24063281 |
2013 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nuclear IRS-1 was also detected by cells expressing the SV40 T-antigen, v-Src, in immortalized fibroblasts stimulated with IGF-I, in hepatocytes, 32D cells, and in an osteosarcoma cell line.
|
22454254 |
2012 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-1R is an independent prognostic marker for osteosarcoma patients and increased expression of this molecular is correlated with metastasis of osteosarcoma.
|
21866554 |
2012 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that marked reduction in serum IGF-I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma.
|
19132750 |
2009 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we also observed that suppression of IGF-1R could reduce the invasiveness of osteosarcoma cells and enhance their radiosensitivity.
|
19229591 |
2009 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of IGF-I occurs in tumors diagnosed in childhood (osteosarcoma, Wilms tumor, neuroblastoma, etc.) and in adults (breast, ovaries, colon and prostate cancer).
|
17166755 |
2007 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional studies are needed to determine how IGF-1/IGF-1R interactions contribute to the malignant phenotype of OS.
|
15095405 |
2004 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We measured the release of sALP activity from human osteosarcoma (SaOS-2) cells and normal human bone cells, under basal conditions and in response to agents that increased apoptosis (TNF-a, okadiac acid) and agents that inhibit apoptosis (IGF-I, calpain, and caspase inhibitors).
|
12037623 |
2001 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these results support the conclusions that in MG-63 cells (i) transcriptional rather post-transcriptional mechanisms are involved in the IGF-I-induced increase of IGFBP-3; (ii) the abundance of GH-R is very low at the plasma membrane level; (iii) the dowstream GH-signaling cascade is fully functional in this human osteosarcoma cell line; and (iv) the endogenous IGFBP-3 gene is not responsive to hGH in human MG-63 osteosarcoma cells.
|
11325513 |
2001 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of extracellular signal-regulated kinases 1 and 2 by insulin-like growth factor I in human osteosarcoma MG-63 cells.
|
10226783 |
1999 |