|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.
|
21823995 |
2011 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
There was no significant difference in the levels of transcripts for IGF1, insulin receptor, or IGF2R between normal and IUGR term placentas.
|
9491374 |
1998 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Early T depressed serum insulin-like growth factor 1 and caused intrauterine growth restriction (IUGR; P < 0.0005).
|
30095996 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, at 28 weeks' gestation there was increased IGF2 (3.9-fold), placental growth hormone (2.7-fold), and IGF BP2 (2.1-fold) expression in maternal blood in women destined to develop FGR at term (P < .05).
|
23583218 |
2013 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Changes in GH/IGF-1 axis in intrauterine growth retardation: consequences of fetal programming?
|
19623512 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Intraplacental gene transfer of IGF-1 prevents FGR induced cardiac dysfunction.
|
28099426 |
2017 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In addition to imprinted genes, the microarray data highlighted non-imprinted genes acting in endocrine signaling (LEP, CRH, HPGD, INHBA), tissue growth (IGF1), immune modulation (INDO, PSG-family genes), oxidative metabolism (GLRX), vascular function (AGTR1, DSCR1) and metabolite transport (SLC-family solute carriers) as differentially expressed in IUGR vs. non-IUGR placentae.
|
16125225 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Insulin-like growth factor I gene deletion causing intrauterine growth retardation and severe short stature.
|
9401537 |
1997 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The FGR(W)-FGR(L) infants showed the lowest mean values of IGF1 (126.2+/-3.2) and IGFBP3 (0.86+/-0.03).
|
16835759 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate that the molecular machinery necessary for transcriptional control of proliferation remains intact in IUGR fetal myoblasts, indicating that in vivo factors such as reduced insulin and IGF1, hypoxia and/or elevated counter-regulatory hormones may be inhibiting muscle growth in IUGR fetuses.
|
28053000 |
2017 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Similar perturbations could be observed in human intrauterine growth retardation suggesting the IGF/IGFBP system is involved in fetal growth, biomineralization, and energetic status in humans.
|
16809446 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The pathogenic <i>IGF1R</i> mutation in this girl led to intrauterine growth retardation followed by partial postnatal catch-up growth.
|
30859796 |
2019 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In this hypothetical scenario, IUGR-induced deficit of IGF-1 causes "diabetic" aging trajectory associated with various metabolic disorders in adulthood, while fetal macrosomia-induced excessive levels of IGF-1 lead to "cancerous" aging trajectory.
|
29626501 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated IGF binding protein (IGFBP)-1 expression associated with fetal growth restriction has been documented.
|
18772238 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The results showed FBG, FINS and HOAM-IR in CUG-FGR group were higher than those in high fat feeding control group (NC+HF), but the content of IGF-1 in blood was lower than that in NC + HF group.
|
29442728 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Women in the IUGR group were smaller than in the control group (p < 0.05), and, using the covariance test (p < 0.05), this was found to be correlated with IGF-I levels but not with EGF or TGF-beta levels.
|
11903419 |
2001 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
There were significantly lower concentrations of glucose, insulin, IGF-1, and IGF-II in the fetal cord blood of pregnancies with IUGR (p<0.05).
|
20106611 |
2010 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Decreased placental expression levels of hPGH, IGF-I and IGFBP-1 were demonstrated in pregnancies with FGR.
|
21212012 |
2011 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.
|
15134305 |
2004 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic defects at the lower end of the GH-IGF-1 axis were identified as a monogenetic cause of intrauterine growth retardation.
|
23182819 |
2012 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
IUGR fetuses had low circulating insulin and insulin-like growth factor 1 (IGF1) and high circulating cortisol.
|
30143557 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We investigated the effects of intra-amniotic IGF1 administration to ovine fetuses with uteroplacental embolisation-induced FGR on phenotypical and physiological characteristics in the 2 weeks after birth.
|
29235113 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
IGFs are low in human SGA newborns; however, only a small minority of these infants have mutations of IGF-related molecules, rather, idiopathic or maternal factors are thought to induce FGR in most of these cases.
|
19202510 |
2008 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Heterozygous mutations in the IGF1 receptor (IGF1R) gene lead to partial resistance to IGF1 and contribute to intrauterine growth retardation (IUGR) with postnatal growth failure.
|
23045302 |
2013 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Finally, IUGR significantly altered the nucleosome-depleted region (NDR) at the in2GHRE of IGF-1 on postnatal day 21, with either complete absence of the NDR or with a shifted NDR exposing only one of two STAT5b DNA binding sites.
|
26487705 |
2015 |