|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?
|
14671411 |
2003 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
IUGR fetuses had low circulating insulin and insulin-like growth factor 1 (IGF1) and high circulating cortisol.
|
30143557 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Insulin-like growth factor I gene deletion causing intrauterine growth retardation and severe short stature.
|
9401537 |
1997 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
A null mutation in igf-1 causes intrauterine growth retardation and perinatal lethality.
|
9731712 |
1998 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Changes in GH/IGF-1 axis in intrauterine growth retardation: consequences of fetal programming?
|
19623512 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Decreased placental expression levels of hPGH, IGF-I and IGFBP-1 were demonstrated in pregnancies with FGR.
|
21212012 |
2011 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Early T depressed serum insulin-like growth factor 1 and caused intrauterine growth restriction (IUGR; P < 0.0005).
|
30095996 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated IGF binding protein (IGFBP)-1 expression associated with fetal growth restriction has been documented.
|
18772238 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Finally, IUGR significantly altered the nucleosome-depleted region (NDR) at the in2GHRE of IGF-1 on postnatal day 21, with either complete absence of the NDR or with a shifted NDR exposing only one of two STAT5b DNA binding sites.
|
26487705 |
2015 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.
|
21823995 |
2011 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Heterozygous mutations in the IGF1 receptor (IGF1R) gene lead to partial resistance to IGF1 and contribute to intrauterine growth retardation (IUGR) with postnatal growth failure.
|
23045302 |
2013 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
IGFs are low in human SGA newborns; however, only a small minority of these infants have mutations of IGF-related molecules, rather, idiopathic or maternal factors are thought to induce FGR in most of these cases.
|
19202510 |
2008 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In addition to imprinted genes, the microarray data highlighted non-imprinted genes acting in endocrine signaling (LEP, CRH, HPGD, INHBA), tissue growth (IGF1), immune modulation (INDO, PSG-family genes), oxidative metabolism (GLRX), vascular function (AGTR1, DSCR1) and metabolite transport (SLC-family solute carriers) as differentially expressed in IUGR vs. non-IUGR placentae.
|
16125225 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In this hypothetical scenario, IUGR-induced deficit of IGF-1 causes "diabetic" aging trajectory associated with various metabolic disorders in adulthood, while fetal macrosomia-induced excessive levels of IGF-1 lead to "cancerous" aging trajectory.
|
29626501 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Intraplacental gene transfer of IGF-1 prevents FGR induced cardiac dysfunction.
|
28099426 |
2017 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
LHGDN |
Low intrauterine IGF-I serum levels may account for thinner and stiffer umbilical arteries in IUGR infants in comparison to AGA infants thereby providing a potential link to arterial hypertension in adulthood.
|
19070892 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, at 28 weeks' gestation there was increased IGF2 (3.9-fold), placental growth hormone (2.7-fold), and IGF BP2 (2.1-fold) expression in maternal blood in women destined to develop FGR at term (P < .05).
|
23583218 |
2013 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Novel functional role of GH/IGF-I in neonatal lung myofibroblasts and in rat lung growth after intrauterine growth restriction.
|
30047284 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
ModifyingMutation
|
phenotype |
RGD |
Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta.
|
24239160 |
2014 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Similar perturbations could be observed in human intrauterine growth retardation suggesting the IGF/IGFBP system is involved in fetal growth, biomineralization, and energetic status in humans.
|
16809446 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.
|
15134305 |
2004 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The FGR(W)-FGR(L) infants showed the lowest mean values of IGF1 (126.2+/-3.2) and IGFBP3 (0.86+/-0.03).
|
16835759 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of our study was to determine the ontogeny of key IGF axis genes and other growth regulating imprinted genes in the placenta and to characterize patterns of placental gene expression associated with intrauterine growth restriction (IUGR).
|
22154689 |
2012 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The pathogenic <i>IGF1R</i> mutation in this girl led to intrauterine growth retardation followed by partial postnatal catch-up growth.
|
30859796 |
2019 |