|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We critically summarize emerging biological mechanisms linking obesity to cancer encompassing insulin resistance and abnormalities of the IGF-I system and signaling; sex hormones biosynthesis and pathway; subclinical chronic low-grade inflammation and oxidative stress; alterations in adipokine pathophysiology; factors deriving from ectopic fat deposition; microenvironment and cellular perturbations including vascular perturbations, epithelial-mesenchymal transition, endoplasmic reticulum stress and migrating adipose progenitor cells; disruption of circadian rhythms; dietary nutrients; factors with potential significance such as the altered intestinal microbiome; and mechanic factors in obesity and cancer.
|
30445141 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity-induced high levels of insulin and insulin-like growth factor-1 in the stem cell niche are found to impact proliferation in rodents indicating that insulin and insulin-like growth factor-1 receptors may play a role in modulating intestinal epithelial stem cell proliferation.
|
29950119 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dysregulation of the IGF system has been implicated in the pathogenesis of obesity, diabetes, and diabetes complications such as nephropathy, but little is known about the genomics of the IGF system in health and disease.
|
16306374 |
2005 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that IGF-I/IR genetic variants interact with obesity, physical activity, and exogenous E, altering postmenopausal CRC risk, through IGF-I/IR traits, but also through different pathways.
|
29023587 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is in keeping with the pivotal role of the insulin/IGF pathway in longevity determination from model organisms to primates, with the association between obesity and age-related disorders, and with the dramatic acceleration of senescence by diabetes.
|
23374718 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth hormone insensitivity syndrome (GHIS) is caused by a defective growth hormone receptor (GHR) and is associated with insulin-like growth factor-I (IGF-I) deficiency, severely short stature and, from adolescence, fasting hyperglycemia and obesity.
|
21968387 |
2011 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, obesity is associated with reduced spontaneous and stimulated GH secretion and basal IGF-1 levels.
|
26732027 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors.
|
31527400 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene expression analysis revealed a significant association between obesity status and both IGF-1R (P = 0·021) and IGF-1 (P = 0·031) in tumours.
|
22241325 |
2012 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these results suggest that obesity enhances local invasion of breast cancer cells through increased expression of IGF-1 by mammary ASCs, and weight loss may reverse this tumor-promoting phenotype.
|
30317122 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This recessively transmitted hereditary disease, characterized clinically by dwarfism and obesity and biochemically by high levels of serum human growth hormone accompanied by low serum concentrations of insulin-like growth factor I, is diagnosed mainly in inbred societies of Asian Jews, Arabs, Iranians, Italians, and Spaniards or their descendants.
|
8374676 |
1993 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Higher PEGV doses at start and a more rapid up-titration are necessary in patients with obesity and/or IGF-1 > 2.7 × ULN.
|
29080965 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypersecretion of IGF1 causes increased expression of lipogenic genes via activating the protein kinase B (PKB; also known as Akt)-mammalian target of rapamycin (mTOR) pathway in adipose tissues, which contributes to the development of obesity, diabetes, and hepatic steatosis as the KI mice age.
|
27307439 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Obesity is a growing global epidemic.Increasing evidence suggests that the GH-IGF-I axis plays an important role in regulating adiposity and insulin sensitivity.
|
20105189 |
2010 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries.
|
30295509 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver.
|
26741958 |
2016 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the expression of candidate genes involved in adipocyte proliferation and/or differentiation [CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPdelta, GATA domain-binding protein 3 (GATA3), C/EBPbeta, peroxisome proliferator-activated receptor (PPAR) gamma2, signal transducer and activator of transcription 5A (STAT5A), Wnt-10b, tumor necrosis factor alpha, sterol regulatory element-binding protein 1c (SREBP1c), 11 beta-hydroxysteroid dehydrogenase, PPARG angiopoietin-related protein (PGAR), insulin-like growth factor 1, PPARgamma coactivator 1alpha, PPARgamma coactivator 1beta, and PPARdelta] in subcutaneous adipose tissue from 42 obese individuals with type 2 diabetes and 25 non-diabetic subjects matched for age and obesity.
|
17030965 |
2006 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
A cross-sectional study compared plasma concentration of cGP, IGF-1 and IGF binding protein (IGFBP)-3 in women with obesity and/or hypertension to normal controls 6-year postpartum using UPLC-MS and ELISA.
|
29921371 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effects of obesity throughout life on the IGF axis and racial differences in breast cancer risk require study.
|
19786462 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that IGF-I/IR genetic variants interact with obesity and lifestyle factors, altering cancer risk partially through pathways other than IGF-I/IR traits.
|
28478612 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review discussed specifically the role of IR isoforms as well as IGF-IR in diabetes and its associated complications as obesity and atherosclerosis.
|
29201918 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
FMD was found to be within normal limits in non-IGF-I-treated adult patients with LS, despite congenital absence of IGF-I and obesity.
|
17320443 |
2007 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The treatment of LS is recombinant IGF-1, which stimulates the linear growth but increases the degree of obesity.
|
26401581 |
2015 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings are relevant not only to ongoing clinical trials of drug candidates that target IGF-I and/or insulin receptors, but also to the hypothesis that obesity-associated hyperinsulinemia mediates the adverse effect of obesity on prostate cancer prognosis.
|
18785179 |
2009 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study shows the existence of a high prevalence of GH-IGF-1 dysfunction in patients with both FM and obesity, presumably as a consequence of the obese rather than fibromyalgic condition.
|
28744309 |
2017 |