|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We critically summarize emerging biological mechanisms linking obesity to cancer encompassing insulin resistance and abnormalities of the IGF-I system and signaling; sex hormones biosynthesis and pathway; subclinical chronic low-grade inflammation and oxidative stress; alterations in adipokine pathophysiology; factors deriving from ectopic fat deposition; microenvironment and cellular perturbations including vascular perturbations, epithelial-mesenchymal transition, endoplasmic reticulum stress and migrating adipose progenitor cells; disruption of circadian rhythms; dietary nutrients; factors with potential significance such as the altered intestinal microbiome; and mechanic factors in obesity and cancer.
|
30445141 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors.
|
31527400 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries.
|
30295509 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study examined the effects cGP treatment on synaptic expression and their association with IGF-1, IGF binding protein (IGFBP)-2 and cGP concentrations in the brain of rats with high fat diet (HFD)-induced obesity.
|
31146894 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cross-sectional associations were observed between IHTG and IGF1 (β = -0.51; 95% CI, -0.82 to -0.20), IGFBP1 (β = -4.2; 95% CI, -7.7 to -0.7), and FGF21 (β = 2.1; 95% CI, 1.3 to 2.9) in lean men and men with abdominal obesity combined.
|
30753672 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The impact of IGF-I, puberty and obesity on early retinopathy in children: a cross-sectional study.
|
31029141 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that 1) GH signaling is normal in obesity, 2) in the obese state, the preservation of IGF-I with fasting and the augmented GH-induced central insulin resistance indicate increased hepatic GH sensitivity, 3) blunted GH levels in obesity may protect against insulin resistance without compromising IGF-I status.
|
30576246 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls.
|
30350467 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity-induced high levels of insulin and insulin-like growth factor-1 in the stem cell niche are found to impact proliferation in rodents indicating that insulin and insulin-like growth factor-1 receptors may play a role in modulating intestinal epithelial stem cell proliferation.
|
29950119 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these results suggest that obesity enhances local invasion of breast cancer cells through increased expression of IGF-1 by mammary ASCs, and weight loss may reverse this tumor-promoting phenotype.
|
30317122 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Higher PEGV doses at start and a more rapid up-titration are necessary in patients with obesity and/or IGF-1 > 2.7 × ULN.
|
29080965 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
A cross-sectional study compared plasma concentration of cGP, IGF-1 and IGF binding protein (IGFBP)-3 in women with obesity and/or hypertension to normal controls 6-year postpartum using UPLC-MS and ELISA.
|
29921371 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reports on GH and IGF-I levels in obese individuals are controversial, with normal and reduced GH-IGF-I levels having been reported in this group of patients.
|
29150385 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of growth hormone on bioactive IGF in overweight/obese women.
|
29679919 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that IGF-I/IR genetic variants interact with obesity, physical activity, and exogenous E, altering postmenopausal CRC risk, through IGF-I/IR traits, but also through different pathways.
|
29023587 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, obesity is associated with reduced spontaneous and stimulated GH secretion and basal IGF-1 levels.
|
26732027 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that IGF-I/IR genetic variants interact with obesity and lifestyle factors, altering cancer risk partially through pathways other than IGF-I/IR traits.
|
28478612 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review discussed specifically the role of IR isoforms as well as IGF-IR in diabetes and its associated complications as obesity and atherosclerosis.
|
29201918 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study shows the existence of a high prevalence of GH-IGF-1 dysfunction in patients with both FM and obesity, presumably as a consequence of the obese rather than fibromyalgic condition.
|
28744309 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specific amino acids, such as leucine, have also been implicated in increasing later obesity risk maybe via specific actions on insulin-like growth factor I.
|
27749711 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This approach revealed that most of the components of the GH/insulin/IGF1 regulatory axis are present in PGs, where their expression pattern is altered under obesity conditions and after an acute insulin treatment (e.g.
|
28244645 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Obesity might affect the basal ovarian release of T or IGF-I and increases the sensitivity of ovaries to the action of benzene but decreases their responsiveness to xylene and YS.
|
28772093 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bioavailable IGF-I is potentially important in racial disparities in obesity-related breast and CR cancer risk between postmenopausal AA and white women.
|
27749737 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the novel finding of this study is that while IGF-1 receptor-mediated Akt activation contributes to cardiac hypertrophy, it is not involved in mTOR activation and autophagy suppression in obesity and T2DM.
|
28987875 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Maternal obesity programs reduced leptin signaling in the pituitary and altered GH/IGF1 axis function leading to increased adiposity in adult sheep offspring.
|
28771488 |
2017 |