Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IGF1 and IGF2 showed longitudinal stability in single AAb+ subjects, but IGF1 levels decreased over time in subjects with multiple AAb and those who progressed to type 1 diabetes, particularly post-diagnosis.
|
31826866 |
2020 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D.
|
29744370 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A longitudinal study of serum insulin-like growth factor-I levels over 6 years in a large cohort of children and adolescents with type 1 diabetes mellitus: A marker reflecting diabetic retinopathy.
|
29663652 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum IGF-1 levels and the IGF-1 standard deviation score were significantly lower in type 1 diabetes patients compared with controls.
|
30900527 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with T1D had lower IGF-1 and IGFBP-3 and higher IGFBP-1 and GH than controls.
|
29989677 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF and IGF-1 baseline serum levels were significantly lower in the T1DM patients compared to the healthy controls, but we found that ExInt and ExC significantly increase the secretion of BDNF and IGF-1 levels.
|
30179684 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
This brief review discusses some of the interactions between the GH/IGF-I axis and T1D pathology, and vice-versa.
|
29249623 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
We test the hypotheses that osteogenesis of bone marrow-derived stromal cells (BMSCs) and periosteum-derived cells (PDCs), two critical skeletal progenitors in long bone healing, are both impaired in T1DM and that they respond differentially to osteogenic bone morphogenetic proteins (BMPs) and/or insulin-like growth factor-1 (IGF-1) rescue.
|
28283030 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data showed for the first time that vitamin D intake could significantly improve fasting plasma glucose, insulin, and IGF-I in an experimental type 1 diabetes model.
|
28961553 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize the clinical studies that address the alterations in the GH/IGF-I axis, linear growth velocity, and BMD in children and adolescents with T1DM; and we review the possible molecular mechanisms that may contribute to an attenuation of linear growth and to the reduction in the acquisition of peak bone mass in the child and adolescent with T1DM.
|
28482269 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the association between bone mineral density and insulin-like growth factor 1 (IGF1), insulin-like growth factor 1 receptor (IGF1R) and transforming growth factor beta 1 (TGFB1) expressions in children and adolescents with T1D.
|
26663878 |
2016 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the injection of TGF, IGF and FGF into human IVDs may induce unwanted blood vessel ingrowth, which accelerates the process of IDD, the injection of GDF-5 may not have the same effect.
|
25547527 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Reducing blood glucose levels in TIDM mice with an orally administered extract of sericin from hIGF-I-transgenic silkworm cocoons.
|
24632065 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We therefore examined the association between common genetic variation in IGF1 and predisposition to type 1 diabetes, childhood growth and metabolism.
|
18317720 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether an IGF-I gene promoter polymorphism influenced the development of persistent MA in type 1 diabetes.
|
17218729 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results provide the first evidence for an association of IGF1 with T1D and imply that co-inheritance of these functional genetic variants of IGF1 and insulin predispose to T1D.
|
15140033 |
2004 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, our results indicate that local expression of IGF-I in beta cells regenerates pancreatic islets and counteracts type 1 diabetes, suggesting that IGF-I gene transfer to the pancreas might be a suitable therapy for this disease.
|
11994404 |
2002 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent growth faltering is thought to be related to impairment of the GH/IGF-1 axis but children with T1DM are also more at risk of hypothyroidism and coeliac disease.
|
12373017 |
2002 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that locally produced IGF-I from cultured islets may be beneficial in maintaining beta cell function and promoting islet survival before and following islet transplantation as a potential therapy for type I diabetes.
|
11175313 |
2000 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group.
|
10189536 |
1999 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recombinant human insulin-like growth factor-I abolishes changes in insulin requirements consequent upon growth hormone pulsatility in young adults with type I diabetes mellitus.
|
9440474 |
1998 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IGF-I dose-response curve was similar for CMCs of control and IDDM individuals, but both the basal and maximal response to IGF-I were lower in the diabetic group (P < .01).
|
8177047 |
1994 |