Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis.
|
28119027 |
2017 |
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.
|
12843293 |
2003 |
Mental Retardation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia.
|
20933621 |
2011 |
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia.
|
20933621 |
2011 |
Cleft Palate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia.
|
20933621 |
2011 |
Cleft palate, isolated
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia.
|
20933621 |
2011 |
Uranostaphyloschisis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia.
|
20933621 |
2011 |
Severe myopia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia.
|
20933621 |
2011 |
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our data demonstrate that AMIGO2 is important in regulating T-cell functions and EAE, and may be harnessed as a potential therapeutic target for multiple sclerosis.
|
28119027 |
2017 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma.
|
29149598 |
2017 |
Metastatic melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma.
|
29149598 |
2017 |
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of Amigo2 in QRsP-11 cells increased liver endothelial cell adhesion and liver metastasis.
|
28272394 |
2017 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In this report, we show that DEGA/AMIGO-2 mRNA is differentially expressed in approximately 45% of tumor versus normal tissue from gastric adenocarcinoma patients.
|
15107827 |
2004 |
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
|
12843293 |
2003 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RNA sequencing (RNA-seq), secretome, and epigenome analysis of K14+ and K14- cells led to the identification of amphoterin-induced protein 2 (Amigo2) as a new cell invasion driver whose expression correlated with decreased relapse-free survival in patients with TP53 wild-type (WT) breast cancer.
|
29924804 |
2018 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RNA sequencing (RNA-seq), secretome, and epigenome analysis of K14+ and K14- cells led to the identification of amphoterin-induced protein 2 (Amigo2) as a new cell invasion driver whose expression correlated with decreased relapse-free survival in patients with TP53 wild-type (WT) breast cancer.
|
29924804 |
2018 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The role of AMIGO2 in tumour research is well-studied, but its role in ischemic heart diseases is seldom reported.
|
29718531 |
2019 |
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of AMIGO2 in tumour research is well-studied, but its role in ischemic heart diseases is seldom reported.
|
29718531 |
2019 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Thus, Amigo2 regulated tumour cell adhesion to liver endothelial cells and formation of liver metastases.
|
28272394 |
2017 |
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We have discovered DEGA, a novel cDNA differentially expressed in human gastric adenocarcinomas.
|
15107827 |
2004 |