Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE The role of AMIGO2 in tumour research is well-studied, but its role in ischemic heart diseases is seldom reported. 29718531 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Thus, Amigo2 regulated tumour cell adhesion to liver endothelial cells and formation of liver metastases. 28272394 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE In this report, we show that DEGA/AMIGO-2 mRNA is differentially expressed in approximately 45% of tumor versus normal tissue from gastric adenocarcinoma patients. 15107827 2004
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.010 Biomarker disease BEFREE The role of AMIGO2 in tumour research is well-studied, but its role in ischemic heart diseases is seldom reported. 29718531 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 AlteredExpression disease BEFREE RNA sequencing (RNA-seq), secretome, and epigenome analysis of K14+ and K14- cells led to the identification of amphoterin-induced protein 2 (Amigo2) as a new cell invasion driver whose expression correlated with decreased relapse-free survival in patients with TP53 wild-type (WT) breast cancer. 29924804 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE RNA sequencing (RNA-seq), secretome, and epigenome analysis of K14+ and K14- cells led to the identification of amphoterin-induced protein 2 (Amigo2) as a new cell invasion driver whose expression correlated with decreased relapse-free survival in patients with TP53 wild-type (WT) breast cancer. 29924804 2018
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.010 Biomarker disease BEFREE AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis. 28119027 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.010 Biomarker disease BEFREE Collectively, this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. 29149598 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.010 Biomarker disease BEFREE Collectively, our data demonstrate that AMIGO2 is important in regulating T-cell functions and EAE, and may be harnessed as a potential therapeutic target for multiple sclerosis. 28119027 2017
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma 		0.010 Biomarker disease BEFREE Collectively, this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. 29149598 2017
CUI: C0494165
Disease: Secondary malignant neoplasm of liver
Secondary malignant neoplasm of liver 		0.010 AlteredExpression disease BEFREE Forced expression of Amigo2 in QRsP-11 cells increased liver endothelial cell adhesion and liver metastasis. 28272394 2017
CUI: C0008925
Disease: Cleft Palate
Cleft Palate 		0.010 Biomarker disease BEFREE Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia. 20933621 2011
CUI: C0025362
Disease: Mental Retardation
Mental Retardation 		0.010 Biomarker disease BEFREE Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia. 20933621 2011
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.010 Biomarker disease BEFREE Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia. 20933621 2011
CUI: C1837218
Disease: Cleft palate, isolated
Cleft palate, isolated 		0.010 Biomarker disease BEFREE Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia. 20933621 2011
CUI: C2981150
Disease: Uranostaphyloschisis
Uranostaphyloschisis 		0.010 Biomarker disease BEFREE Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia. 20933621 2011
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.010 Biomarker group BEFREE Among these, it is hypothesized that haploinsufficiency of AMIGO2 is potentially responsible for the mental retardation of this patient, and of COL2A1 for the cleft palate and high myopia. 20933621 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 AlteredExpression group BEFREE We have discovered DEGA, a novel cDNA differentially expressed in human gastric adenocarcinomas. 15107827 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 GeneticVariation disease LHGDN Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. 12843293 2003
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.010 GeneticVariation disease LHGDN Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. 12843293 2003