Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample.
|
7475820 |
1995 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
No relation was found between measurements of cognitive decline and the presence of the ApoE epsilon4 allele.
|
8971103 |
1996 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The purpose of this study was to determine whether apoE genotypes differentially influence the course of cognitive decline in AD dementia.
|
8757018 |
1996 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The analysis of cardiovascular risk factors showed that the risk of cognitive decline was highest in subjects with both APOE*4 and a high cholesterol level, high fibrinogen level, normal blood pressure, or diabetes mellitus.
|
8969786 |
1996 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
This suggests that apoE genotyping will have limited utility as a diagnostic or prognostic indicator of cognitive decline in individuals.
|
8687193 |
1996 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
These observations suggest that the rate of cognitive decline increases with age and that APOE and other familial/genetic factors influence the onset age throughout life.
|
9106542 |
1997 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Although the APOE epsilon 4 allele is a risk factor for Alzheimer's disease, there is no support of a strong association between APOE epsilon 4 dosage and rate of cognitive decline.
|
9137113 |
1997 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Genetic variability at APOE and APP was not significantly associated with evidence of cognitive decline.
|
9189907 |
1997 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Apolipoprotein E epsilon 4 is associated with cognitive decline in community-dwelling nondemented women.
|
9311354 |
1997 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Association between apolipoprotein E epsilon4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia.
|
9708956 |
1998 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that the consequences of APOE epsilon 4 and atherosclerosis are not independent, and that particularly APOE epsilon 4 carriers with atherosclerosis are at increased risk of cognitive decline.
|
9700643 |
1998 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
APOE-epsilon4 homozygosity is associated with a faster rate of cognitive decline, whereas the epsilon2 allele slows disease progression.
|
9674794 |
1998 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 (epsilon 4) with Alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the ApoE epsilon 4 allele.
|
9549778 |
1998 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Thus, the purpose of this study was twofold: (1) to examine very early changes in olfactory functioning due to AD and (2) to examine the role of ApoE in olfactory functioning in people at risk for AD by virtue of early cognitive decline.
|
9929677 |
1998 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the combined effect of the apolipoprotein E epsilon4 (ApoE*4) allele and midlife cardiovascular risk factors on cognitive decline.
|
9633697 |
1998 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
To examine the association between subclinical CVD and decline in cognitive functioning in the elderly and to examine effect modification by the APOE genotype of the association between subclinical disease and cognitive decline.
|
10404910 |
1999 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Unexplained olfactory dysfunction in the presence of one or more APOE-epsilon4 alleles is associated with a high risk of cognitive decline.
|
10534255 |
1999 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
A single copy of the APOE-4 allele was associated with lowered inferior parietal, lateral temporal, and posterior cingulate metabolism, which predicted cognitive decline after 2 years of longitudinal follow-up.
|
10811879 |
2000 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The Apolipoprotein-E (APOE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD) and cognitive decline in older adults.
|
10910416 |
2000 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The lack of association between APOE epsilon 4 carrier status and mortality, or development of dementia, or cognitive decline in these very elderly people, whether analyzed in the whole population or among the nondemented subjects only, suggests that the APOE epsilon 4 effect in younger subjects is age-dependent, and that it is no longer present in very old age.
|
10668704 |
2000 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The authors sought to determine whether estrogen use modifies the association between APOE-epsilon4 and cognitive decline.
|
10822435 |
2000 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Moreover, the combined effect of the presence of at least one APOE epsilon4 allele and ACE DD homozygosity was a risk factor for cognitive decline.
|
10794851 |
2000 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The apoE polymorphism also affects response to head trauma, cognitive decline upon ageing and several other disorders.
|
10766403 |
2000 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Recently, Tardiff and colleagues have suggested that the presence of the apolipoprotein E, epsilon4 allele was associated with increased likelihood of cognitive decline after coronary artery bypass grafting.
|
11269459 |
2001 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study.
|
11535238 |
2001 |