Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy.
|
31567873 |
2020 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The apolipoprotein E status was associated with the progression of cognitive decline.
|
30640256 |
2020 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals.
|
31760549 |
2020 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The results of the GEE adjusted for age, years of education, sex, disease duration, baseline MMSE score, time, apolipoprotein E (APOE) ε4 carrier status, use of medications (acetylcholinesterase inhibitors or N-methyl-D-aspartate receptor antagonists), and hospitalization rates and showed that patients with more than three VRFs had more rapid cognitive decline than patients without VRFs (MMSE, P = .02; CDRSB, P = .001) as well as patients with three or fewer VRFs (MMSE, P = .009; CDRSB, P = .02).
|
31587263 |
2020 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
We evaluated interactions between cortical expression of 10 VEGF gene family members and APOE-ε4 genotype to clarify which VEGF genes modify the association between APOE-ε4 and cognitive decline.
|
31791659 |
2020 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The ε4 allele, compared to the common ε3 allele, of the human apolipoprotein E gene (ApoE) is associated with accelerated cognitive decline and increased risks for Alzheimer's disease.
|
31626305 |
2020 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers.
|
31591322 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
To examine the racial differences in the association of the APOEɛ4 allele with incident Alzheimer's dementia and cognitive decline.
|
31561363 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
However, it is unclear whether APOE modifies risk for cognitive decline in normal aging.
|
30730162 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Although previous studies have investigated the effects of the apolipoprotein E (APOE) ɛ4 genotype on the default mode network (DMN) in the Alzheimer's disease (AD) spectrum, it is still unclear how the APOE genotype regulates the DMN and subsequently affects cognitive decline in the AD spectrum.
|
31282419 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Among individuals with normal cognition (NC; n = 415), mild cognitive impairment (MCI; n = 870), and AD (n = 334), we investigated the longitudinal associations of APOE4 genotype and sex with cognitive decline over 13 years.
|
31127771 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers.
|
31159873 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The present study might suggest that protective effects against cognitive decline in APOE4 (+) MCI subjects exist.
|
31319510 |
2019 |
Mental deterioration
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
To examine the individual and interactive associations of APOE and objectively-measured physical activity (PA) and sedentary activity with cognitive decline.
|
31450492 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Risk factors for cognitive decline include male sex and apolipoprotein E genotype.
|
31732016 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Age (B = -0.07, SE = 0.01), APOE*4 carriage (B = -0.41, SE = 0.18), and diabetes (B = -0.18, SE = 0.10) were independently associated with faster cognitive decline (p < 0.05 for all).
|
31335910 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
In addition to being the greatest genetic risk factor for Alzheimer's disease, expression of the ɛ4 allele of apolipoprotein E can lead to cognitive decline during ageing that is independent of Alzheimer's amyloid-β and tau pathology.
|
30496349 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Herpes Simplex Virus, APOEɛ4, and Cognitive Decline in Old Age: Results from the Betula Cohort Study.
|
30636735 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The combination of chronic cerebral hypoperfusion and ApoE deficiency induced cognitive decline and cerebrovascular pathology, including white matter damage, multiple microinfarctions, and degeneration of cerebral microcirculation.
|
29053032 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The association of the APOE genotypes with cognitive decline was not different between AAs and EAs.
|
30584655 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Previous research has investigated whether the apolipoprotein E (APOE) ε4 allele, which is associated with an increased risk of cognitive decline, is also associated with hearing loss in older people.
|
31592904 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
C1q-ApoE complexes in human ChPs, Aβ plaques, and arteries correlated with cognitive decline and atherosclerosis, respectively.
|
30692699 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
One subgroup, the Lower Cognitive Class, more likely to carry an APOE e4 allele, may be at a greater risk for subsequent cognitive decline, even though current performance on neuropsychological testing is within normal limits.
|
31232250 |
2019 |
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Despite evidence of a relationship between Apolipoprotein E (APOE) ε4+ and later-life cognitive decline, the lifespan effects of carrying an ε4+ allele on cognitive ageing are not well understood.
|
30472114 |
2019 |
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Apolipoprotein-ε4 (APOE-ε4) - common variant is a major genetic risk factor for cognitive decline and Alzheimer's disease (AD).
|
31541246 |
2019 |