|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.
|
17655277 |
2007 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Such findings support the active role of placental LPL and APOE in the metabolism of maternal lipoproteins and suggest that fetal genes may modulate the risk for problems related to maternal dyslipidemia (preeclampsia, pancreatitis, and future cardiovascular disease).
|
16106048 |
2005 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To better inform prevention, future consideration should be given toward managing dyslipidemia in women carrying the APOE ɛ4 allele.
|
30689578 |
2019 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
ApoE4 allele is associated with obesity independent of dyslipidemia in women but not men with a family history of diabetes.
|
11553047 |
2001 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A similar phenotype of combined dyslipidemia was induced in apoE(-/-) or apoE(-/-) x LDLr(-/-) mice after infection with a low dose (4 x 10(8) pfu) of an adenovirus expressing the apoE4[R142V/R145V] mutant previously shown to be defective in receptor binding.
|
16339113 |
2006 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further screening for common apoE gene variants in individuals at risk for dyslipidemia may reveal abnormal heteroduplex patterns and uncover further mutations in this important lipid-regulating gene.
|
15514092 |
2005 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Only APOE*4 conferred a risk against longevity and was associated with high-cholesterol (hTC) and mixed dyslipidemia for oldest-old females.
|
24746514 |
2014 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Apolipoprotein E (apo E) deficiency (or its abnormalities in humans) is associated with a series of pathological conditions including dyslipidemia, atherosclerosis, Alzheimer's disease, and shorter life span.
|
11726538 |
2001 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
APOE genotypes are associated with lipid levels in patients with RA, and may contribute to dyslipidemia in some patients.
|
23613766 |
2013 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Dyslipidemia and apolipoprotein E4 (APOE ϵ4) allele are risk factors for age-related cognitive decline, but how these risks are modified by human immunodeficiency virus (HIV) infection is unclear.
|
27448678 |
2016 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Dyslipidemia in LPG generally resembles type III hyperlipoproteinemia with elevated serum apolipoprotein E level.
|
30685233 |
2020 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of the ApoE (Apolipoprotein E) gene and their influence on dyslipidemia in HIV-1-infected individuals.
|
25420659 |
2015 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We evaluated the contribution of APOC3 -482C-->T, -455T-->C, and 3238C-->G; epsilon 2 and epsilon 4 alleles of APOE; and TNF -238G-->A to dyslipidemia and lipoatrophy by longitudinally modeling >2600 lipid determinations and 2328 lipoatrophy assessments in 329 ART-treated patients during a median follow-up period of 3.4 years.
|
15809899 |
2005 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE<sup>-/-</sup>) mice fed a high-fat diet to reveal atherosclerosis-induced dyslipidemia.
|
28527370 |
2017 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Compared with APOE*3/*3 homozygotes, patients with the APOE*4 allele had 1.3 times higher risk for CAD after ignoring dyslipidemia, but this risk was modified after adjusting for dyslipidemia.
|
17985658 |
2007 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The objective of this study was to evaluate 1) whether non single nucleotide polymorphisms-coding (non-cSNP) in the apolipoprotein E gene (APOE) identified by resequencing studies contribute to statistically explaining dyslipidemia if variations in the two cSNPs in exon 4 that define the 2, 3, and 4 alleles are ignored, and 2) whether the contribution of these additional SNPs persists when variations in the cSNPs are considered.
|
16317171 |
2006 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The APOE p.Leu167del mutation was also found in the proband's son and granddaughter, neither of whom has splenomegaly or marked dyslipidemia.
|
24314356 |
2014 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
We have previously shown that MGL affects plaque stability in apolipoprotein E (ApoE)-/- mice, an established animal model for dyslipidemia and atherosclerosis.
|
28380440 |
2017 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins.
|
7706948 |
1995 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Apolipoprotein E gene polymorphisms are strong predictors of inflammation and dyslipidemia in rheumatoid arthritis.
|
22174202 |
2012 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
The present study indicates that in the Ouro Preto admixed population the presence of APOE *2 can confer a protective effect, whereas the presence of APOE *4 implies an enhanced risk for dyslipidemia.
|
17224996 |
2007 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
CTD_human |
Adiponectin expression and the cardioprotective role of the vitamin D receptor activator paricalcitol and the angiotensin converting enzyme inhibitor enalapril in ApoE-deficient mice.
|
25037058 |
2014 |
|
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We confirm that human schistosomiasis causes dyslipidemia and report for the first time that certain changes in plasma lipid and lipoprotein levels depend on APOE gene polymorphism.
|
25051269 |
2014 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE).
|
30979683 |
2019 |
|
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Apolipoprotein E (apo E), a genetic determinant of plasma lipid levels and coronary heart disease (CHD) needs to be investigated in Asian Indians since they have a propensity to develop dyslipidemia and accelerated atherosclerosis.
|
12030385 |
2002 |