|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among PD patients without dementia, the APOE ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD.
|
25178429 |
2014 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We apply our method to two genome-wide association data sets and localize both the functional variant REP1 in the α-synuclein gene that conveys susceptibility to Parkinson's disease and the APOE gene responsible for the association signal in the Alzheimer's disease data set.
|
23736218 |
2014 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Task-specific regional activations in Parkinson's disease were linked with genetic variation: the rs4680 polymorphism modulated the effect of levodopa therapy on planning-related activations in the frontoparietal network; the MAPT haplotype modulated parietal activations associated with spatial rotations; and APOE allelic variation influenced the magnitude of activation associated with memory encoding.
|
25080285 |
2014 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile.
|
24175296 |
2013 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All three patients also carried at least one ε4 allele of apolipoprotein E. One individual presented with cognitive impairment without significant parkinsonism; one presented with memory problems followed by bradykinesia; and the third presented with cardinal signs of Parkinson's disease, followed more than a year later by cognitive dysfunction.
|
23124435 |
2013 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TOMM40 and APOE common genetic variants are not Parkinson's disease risk factors.
|
23522842 |
2013 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the role of APOE alleles in PD risk by studying a large sample size and controlling for population substructure.
|
22349451 |
2012 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carrying at least one APOE ε4 allele is associated with more rapid cognitive decline in PD, supporting the idea of a component of shared etiology between PD dementia and Alzheimer's disease.
|
22344634 |
2012 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine the relationship between apolipoprotein E (APOE) polymorphisms to the time to appearance of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.
|
21108621 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The main goal of this work was to describe two MJD patients displaying the parkinsonian triad (tremor, bradykinesia and rigidity), namely on what concerns genetic variation in Parkinson's disease (PD) associated loci (PARK2, LRRK2, PINK1, DJ-1, SNCA, MAPT, APOE, and mtDNA tRNA(Gln) T4336C).
|
22023810 |
2011 |
|
Parkinson Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis.
|
21772670 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study suggested that the ApoE ε4 allele may be associated with a lower PD risk among non-Hispanic Caucasians.
|
21741729 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
As compared with the APOE ε3/ε3 genotype, the 2/ε4 genotype was associated with an increased risk of PD (adjusted odds ratio (OR) = 9.50, 95% (confidence interval) CI = 1.12-80.6).
|
21360299 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The discrepancy among the results of the genetic association studies of APOE genotypes as a risk of susceptibility to PD emphasises that this association merits clarification by the study of a single large homogeneous population.
|
21782446 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A lower initial MMSE score was associated with higher mortality for probable AD, PD, and MCI, while APOE4 predicted mortality for PD and LBD.
|
20389122 |
2010 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prospective, long-term follow-up may still reveal associations between APOE alleles and clinical and neuropsychological progression in PD.
|
20456244 |
2010 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The Apolipoprotein E e4e4 genotype was more common in patients with Parkinson disease (7.4%) than in healthy controls (1.4%; P = .03).
|
19321880 |
2009 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E genotypes in Mexican patients with Parkinson's disease.
|
20037210 |
2009 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The lack of association between the APOE 4 allele and PDD suggests that the pathological process involved in the development of dementia in PD is different from the one that occurs in AD.
|
18930114 |
2008 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The objective of this study was to explore combined effects of four candidate susceptibility genes and two exposures on Parkinson's disease (PD) risk; namely, alpha-synuclein (SNCA) promoter polymorphism REP1, microtubule-associated protein tau (MAPT) H1/H2 haplotypes, apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 polymorphism, ubiquitin carboxy-terminal esterase L1 (UCHL1) S18Y variant, cigarette smoking and caffeinated coffee consumption.
|
18210157 |
2008 |
|
Parkinson Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The novel findings of this study that warrant replication are the evidence for interaction of coffee with APOE, and of smoking with REP1 on PD risk.
|
18210157 |
2008 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The APOE genotype (APOE epsilon2 or APOE epsilon4 alleles) and SNCA-REP1 polymorphism do not seem to influence olfaction in PD.
|
19047559 |
2008 |
|
Parkinson Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our data reveal a molecular link between central pathogenic mechanisms implicated in Parkinson's disease and Alzheimer's disease and suggest that intracellular alpha-synuclein is pathogenic, at least in part, by activation of extracellular signaling pathways involving ApoE.
|
18297066 |
2008 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).
|
17230455 |
2007 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects.
|
17204369 |
2007 |