Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis.
|
31634818 |
2020 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subjected to overexpressed GAS5, overexpressed EZH2, or downregulated ABCA1, the Apolipoprotein E (ApoE)<sup>-/-</sup> mice with atherosclerosis showed increased total cholesterol (TC), free cholesterol (FC), cholesterol ester (CE), low-density lipoprotein (LDL) levels, aortic plaque, and lipid accumulation, accompanied by reduced high-density lipoprotein (HDL) level and cholesterol outflow.
|
31830648 |
2020 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the effect of such lipid-lowering interventions on atherosclerosis in APOE*3-Leiden.CETP mice, a well-established model for hyperlipidemia.
|
31843957 |
2020 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E knockout (ApoE<sup>-/-</sup> ) mice fed a high-fat-diet (HFD) to establish AS model.
|
31232476 |
2020 |
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice.
|
31599473 |
2020 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice.
|
31771811 |
2020 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the effect of SCFAs on hypertensive cardiac damage and atherosclerosis, wild-type NMRI or apolipoprotein E knockout-deficient mice received propionate (200 mmol/L) or control in the drinking water.
|
30586752 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The apolipoprotein E knockout (ApoE -/-) mouse model is well established for the study of terpenoids in the prevention of atherosclerosis.
|
31392210 |
2019 |
Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, ApoE4+ women are more likely to have higher levels of subclinical atherosclerosis if their metabolic phenotype is poor compared with ApoE4+ women without poor metabolic profile and ApoE4- women.
|
31362877 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
44 apolipoprotein E (ApoE)-/- 7 weeks old male rats were randomly divided into normal diet group (NC group) and AS model group (high-fat diet feeding).
|
31002155 |
2019 |
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We recently described that apolipoprotein E (ApoE) deficient mice with a mutation in the fibrillin-1 (Fbn1) gene (ApoE<sup>-/-</sup>Fbn1<sup>C1039G+/-</sup>) develop accelerated atherosclerosis, plaque rupture, myocardial infarction, cerebral hypoxia and sudden death.
|
31085310 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice, double-knockout (DKO) for ApoE (major cholesterol carrier in brain) and PON1 (paroxonase1, reduces oxidative stress), showed severe age-dependent atherosclerosis of the arteries carrying blood to the brain even on normal diet.
|
30714958 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells.
|
30599892 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Acceleratory effects of ambient fine particulate matter on the development and progression of atherosclerosis in apolipoprotein E knockout mice by down-regulating CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells.
|
31513887 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice doubly deficient for CCL1 and Apoe exhibited enhanced atherosclerosis in aorta, which was associated with reduced plasma levels of the anti-inflammatory interleukin 10, an increased splenocyte Th1/Th2 ratio, and a reduced regulatory T cell (Treg) content in aorta and spleen.
|
31121182 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase<sup>+/-</sup> (GK<sup>+/-</sup>) mice are a translatable disease model for glucose control in type 2 diabetes.
|
30949516 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nontraditional cardiovascular risk factors such as lipoprotein(a) (Lp(a)), the genetic polymorphisms of apolipoprotein(a), apolipoprotein E (ApoE), and apolipoprotein B (ApoB) increase the prevalence of atherosclerosis in end-stage renal disease (ESRD) through quantitative and qualitative alterations.
|
31119518 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice.
|
30661353 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sixteen male Fas<sup>-/-</sup> mice were included in the study, sex-matched C57B6/L (B6) and apolipoprotein E-knockout (ApoE<sup>-/-</sup>) mice were negative and positive AS controls, respectively.
|
30235005 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polydatin attenuates atherosclerosis in apolipoprotein E-deficient mice: Role of reverse cholesterol transport.
|
31085374 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice.
|
30925684 |
2019 |
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.
|
31364648 |
2019 |
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Effects of Dimethyl Fumarate on Atherosclerosis in the Apolipoprotein E-Deficient Mouse Model with Streptozotocin-Induced Hyperglycemia Mediated By the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element (Nrf2/ARE) Signaling Pathway.
|
31645538 |
2019 |
Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Among them, 177 proteins were also differentially expressed in diabetic apolipoprotein E deficient (ApoE-/-STZ) mice, suggesting expression changes associated with atherosclerosis independent of the model used.
|
30826357 |
2019 |
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A previous study showed that the omega-6 fatty acid, dihomo-γ-linolenic acid (DGLA), attenuated atherosclerosis in the apolipoprotein E deficient mouse model system.
|
31202985 |
2019 |