Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study compared cognition, amyloid-β, tau, regional brain metabolism and volumes, and the effect of APOE in 83 veterans with and without PTSD defined by the Clinician's Administered PTSD Scale.
|
31771068 |
2020 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE ε4 allele carriers with PTSD have substantially greater cognitive difficulties than ε4 carriers without PTSD.
|
31385647 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The interaction between APOE-ε4 genotype and having a PTSD diagnosis was associated with DNA methylation at CpG site -675 (p = .009).
|
29807071 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
U.S. military veterans who are APOE ε4 allele carriers and exposed to a high number of traumas may be at increased risk for developing PTSD symptoms than ε4 noncarriers.
|
29172227 |
2018 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three hundred and forty-three US veterans were genotyped for apoE and were assessed for their lifetime trauma exposure (trauma score, T) and severity of posttraumatic stress disorder symptoms (PCL).
|
28299413 |
2017 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study showed a significant association between the APOE e4 gene variant and increased risk for developing combat-related PTSD, with an overall effect size of d equal to 0.28 (95% confidence interval: 0.10-0.45) for e4 carriers versus noncarriers.
|
28430712 |
2017 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that PL profiles, together with APOE genotyping, could potentially aid to differentiate diagnosis of mTBI and PTSD and warrant further validation.
|
26714394 |
2016 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of PTSD Re-Experiencing Symptoms.
|
25751510 |
2015 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we began to elucidate these associations by examining the effects of apoE on PTSD severity in combat veterans, and on PTSD-like behavior in mice with human apoE.
|
25857685 |
2015 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although preliminary, these findings suggest that the APOE ε4 allele, in conjunction with exposure to high levels of combat exposure, may increase veterans' risk for developing PTSD.
|
25709077 |
2015 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combat × apoE genotype interaction was significant for both PTSD symptoms (P = .014) and PTSD diagnosis (P = .009).
|
24132908 |
2013 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E gene polymorphism, alcohol use, and their interactions in combat-related posttraumatic stress disorder.
|
23761065 |
2013 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The authors investigated the associations between APOE allele status, memory function, and posttraumatic stress disorder (PTSD) symptom severity in PTSD subjects.
|
16387995 |
2005 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Neuropsychiatric associations of apolipoprotein E alleles in subjects with combat-related posttraumatic stress disorder.
|
16387995 |
2005 |