Hyperhomocysteinemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, hyperhomocysteinemia was induced in apolipoprotein E-deficient mice with 1.7% methionine.
|
29557377 |
2018 |
Hyperhomocysteinemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, non-HHcy and HHcy induced by high-methionine diet in apolipoprotein E-deficient (Apo E<sup>-/-</sup>) mice were comparatively investigated.
|
29171783 |
2017 |
Hyperhomocysteinemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Notably, shikonin treatment effectively attenuated HHcy-accelerated atherosclerotic lesion formation in apolipoprotein E-deficient mice.
|
27903739 |
2017 |
Hyperhomocysteinemia
|
0.300 |
Therapeutic
|
disease |
RGD |
The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet.
|
22762542 |
2012 |
Hyperhomocysteinemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Next, we used angiotensin II-infused male apolipoprotein E-deficient mice and tested whether HHcy contributes to AAA pathogenesis.
|
22912384 |
2012 |
Hyperhomocysteinemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Because apoE-HDL plays a role in amyloid β-protein clearance, these results suggest that two different risk factors, apoE4 and hyperhomocysteinemia, may share a common mechanism that accelerates the pathogenesis of AD in terms of reduced HDL generation.
|
20889503 |
2010 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Vascular risk factors were found significantly more often in the MCI group (p = 0.041), including APOE4 allele (p = 0.018), hyperhomocysteinaemia (p = 0.012) and folate deficiency (p = 0.023).
|
19742390 |
2009 |
Hyperhomocysteinemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Non-enzymatic functions of the BuChE protein, APOE epsilon 4 status and hyperhomocysteinemia influence the progression of pathology, symptom expression, and response to cholinesterase inhibition in a stage-specific manner in neurodegenerative disorders associated with Alzheimer, Lewy body and vascular pathology.
|
19359103 |
2009 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
BuChE-K and APOE epsilon4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline.
|
19006190 |
2009 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we characterized monocyte heterogeneity in Tg-hCBS apoE(-/-) Cbs(-/-) mice and another severe HHcy mouse model (Tg-S466L Cbs(-/-)) with a disease-relevant mutation (Tg-S466L) that lacks hyperlipidemia.
|
19858416 |
2009 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
The ApoE4 allele constitutes a risk factor for hippocampal volume loss in patients with alcohol dependence under the conditions of hyperhomocysteinemia.
|
17420762 |
2008 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The ApoE4 allele constitutes a risk factor for hippocampal volume loss in patients with alcohol dependence under the conditions of hyperhomocysteinemia.
|
17420762 |
2008 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Severe HHcy (plasma Hcy 210 micromol/L) accelerates spontaneous arthrosclerosis in the CBS(-/-)/apoE(-/-) mice, reduces the concentration of circulating HDL, apoA-I, and large HDL particles, inhibits HDL function, and enhances HDL-C clearance.
|
18020970 |
2007 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The risk of high CRP was lower in APOE4 carriers without hyperhomocysteinemia (multivariate-adjusted OR: 0.51; 95% CI: 0.31, 0.85) than in noncarriers.
|
17158432 |
2006 |
Hyperhomocysteinemia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
(3) An analysis of the phenotypic and genotypic CV risk factors demonstrated differences with the reference population only for hyperhomocysteinemia, Lp(a) and ApoE4 allele prevalence, with no notable differences among the participating centers.
|
15151261 |
2004 |