|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety.
|
30905741 |
2019 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety.
|
30905741 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, adoptive transfer of IGF-2-preprogrammed macrophages to EAE mice increased Tregs and alleviated the diseases.
|
30745181 |
2019 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Recent evidence highlights the role of IGF2 in the brain, sustained by data showing its alterations as a common feature across a variety of psychiatric and neurological disorders.
|
30389571 |
2019 |
|
Psychotic Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data suggests that epigenetic activation of the enhancer at IGF2 may enhance dopamine synthesis associated with major psychosis.
|
31053723 |
2019 |
|
Rickets
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further studies are recommended to evaluate Preptin role in treatment of rickets in children.
|
30845974 |
2019 |
|
Nonorganic psychosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggests that epigenetic activation of the enhancer at IGF2 may enhance dopamine synthesis associated with major psychosis.
|
31053723 |
2019 |
|
Carcinoma of anal margin
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also demonstrated that IGF2 expression is mainly due to cancer-associated fibroblasts and that IGF2 secreted by cancer-associated fibroblasts from ASCC samples promotes proliferation of a human ASCC cell line via IGF2 paracrine signalling.
|
30714617 |
2019 |
|
Pregnancy associated hypertension
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We identified one case each of FGR and PIH showing hypomethylation of H19-DMR and IGF2-DMRs only in the placenta, but not in cord blood, from the first case/control set.
|
31370882 |
2019 |
|
Anal squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also demonstrated that IGF2 expression is mainly due to cancer-associated fibroblasts and that IGF2 secreted by cancer-associated fibroblasts from ASCC samples promotes proliferation of a human ASCC cell line via IGF2 paracrine signalling.
|
30714617 |
2019 |
|
Plaque, Amyloid
|
0.010 |
Biomarker
|
disease |
BEFREE |
IGF-2 attenuates memory decline, oxidative stress, cell apoptosis and amyloid plaques in the AD mouse model Tg2576 by activating the PI3K/AKT/CREB signaling pathway.
|
31266549 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Vaccinated mice received the intravenous injection of rhabdomyosarcoma cells to study the effects of anti-IGF2 antibodies against developing metastases.
|
30732578 |
2019 |
|
Toxemia of pregnancy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although H19 and IGF2 have been assessed for their involvement in pregnancy complications including fetal growth restriction (FGR) and pregnancy-induced hypertension (PIH)/hypertensive disorder of pregnancy (HDP) intensively in the last decade, it is still not established whether epimutation at the H19-DMR in the placenta results in pathogenic conditions in pregnancy.
|
31370882 |
2019 |
|
Metastatic Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Metastatic Breast Carcinoma-Associated Fibroblasts Have Enhanced Protumorigenic Properties Related to Increased IGF2 Expression.
|
31515454 |
2019 |
|
Fatty Liver
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Both total fat-adjusted percent liver fat (P = 0.039) and the presence of fatty liver (P = 0.015) were positively associated with IGF2 DMR2a methylation.
|
30277114 |
2018 |
|
Folic Acid Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
The serum parameters assay showed that the concentrations of MTHFR (476.57 vs. 395.27), DHFR (45.056 vs. 38.952), LPL (50.408 vs. 48.677), HCY (4.354 vs. 3.836), LEP (9.951 vs. 8.673), and IGF2 (1209.4 vs. 1027.7) in offspring serum of the FD group were significantly higher than those of the normal folate (NF) group ( P < 0.01).
|
30240347 |
2018 |
|
Gonorrhea
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We investigated IGF2 DMR and LINE1 methylation in the leukocyte DNA and their association with clinicopathological features and prognosis of gastric cancer (GC) patients.
|
28871451 |
2018 |
|
Heart Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The insulin-like growth factor type 2 receptor (IGF2R) overexpression has been implicated in heart disease progression.
|
29136764 |
2018 |
|
Hirschsprung Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study revealed that miR-483-3p derived from IGF2 was associated with Hirschsprung's disease by targeting FHL1 and may provide a new pathway to understand the aetiology of HSCR.
|
30073757 |
2018 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
This study also suggested possible genes related to fetal development such as B-cell lymphoma, LRP10, and IGF-2.
|
29480850 |
2018 |
|
Essential Hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This preliminary study revealed that plasma preptin levels are decreased in patients with essential hypertension, negatively correlated with carotid artery IMT, and significantly lower in patients with carotid atherosclerotic plaques.
|
29724293 |
2018 |
|
Choroid Plexus Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Weight and BMI were significantly associated with the combination of [IGF-2(3580) + IGF2R + IGFBP-3] in the CPP group.
|
30249230 |
2018 |
|
Myelolipoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation between ghrelin and IGF2 expression was observed only in myelolipoma (P = .001).
|
29682767 |
2018 |
|
Embryonal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To address the potential involvement of the IGF2-H19 and DLK1-MEG3 loci in the pathogenesis of embryonal carcinoma (EC), we investigated their genomic imprinting at DMRs in the human PGC-derived EC cell line NTera-2 (NT2).
|
29980981 |
2018 |
|
Congenital contractural arachnodactyly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Modeling of CCA-CAF crosstalk showed that IGF2 expressed by fibroblasts boosted IR/IGF1R signaling in resistant cells.
|
29716918 |
2018 |