Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE The insulin-like growth factor (IGF)2/IGF1 receptor (IGF1R) signaling axis has an important role in intestinal carcinogenesis and overexpression of IGF2 is an accepted risk factor for colorectal cancer (CRC) development. 28534511 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes. 27337954 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE In the present study, we investigated the feasibility of using adenovirus‑mediated siRNA targeting CD147 based on the IGF2 LOI system for targeted gene therapy of CRC. 26397886 2016
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin-like growth factor 2 imprinting. 25625919 2016
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE The aim of this study was to investigate the expression of IGF-2 after 5-aminolevulinic acid (5-ALA)-mediated-PDT in SW620 human colorectal cancer cells with evaluation of cell proliferation and apoptosis and to determine the effects of PDT on the IGF-2 receptor (IGF-2R), IGF-2 binding protein-1 (IGF-2BP-1) and the proapoptotic protein, BAX. 26445041 2016
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE In colorectal cancer the most commonly observed pathway changes are IGF2 overexpression, PIK3CA mutations and PTEN mutations and deletions. 25450577 2015
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 PosttranslationalModification disease BEFREE Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region. 25411283 2015
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE A relationship between IGF2 DMR0 hypomethylation and poor prognosis has been shown in colorectal cancer. 24318096 2014
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system. 23171475 2013
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer. 22840368 2013
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer. 22121898 2012
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE We measured methylation at the IGF2 DMR0 using a bisulfite-pyrosequencing assay with 1178 paraffin-embedded colorectal cancer tissue samples from 2 prospective cohort studies. 20682317 2011
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Plasma levels of IGF-II and IGFBP-2 were measured in 162 patients with CRC before surgery, in paired 15 patients after curative surgery, in 24 patients with advanced colon polyps, and in 114 healthy controls between 2003 and 2006 in National Taiwan University Hospital. 20157191 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. 20479215 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. 19957330 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE These findings support the concept that LOI of IGF2 may be a useful risk factor for CRC predisposition. 19242102 2009
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 PosttranslationalModification disease BEFREE In Wilms tumour and colorectal cancer, biallelic expression of IGF2 has been observed in association with loss of methylation at a DMR in IGF2. 18365005 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. 18541649 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 PosttranslationalModification disease BEFREE Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II. 18619647 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE We review studies of loss of imprinting of insulin-like growth factor 2 in colorectal cancer as an example of such a target for preventive oncology. 17464249 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE This increased risk corresponds to the apparent increased risk of colorectal cancer in patients with LOI of IGF2. 16357124 2006
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Clinicopathological characteristics of colorectal cancers with loss of imprinting of insulin-like growth factor 2. 16432831 2006
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Loss of imprinting (LOI) of the insulin-like growth factor II gene (IGF2) is an epigenetic alteration that results in a modest increase in IGF2 expression, and it is present in the normal colonic mucosa of about 30% of patients with colorectal cancer. 15731405 2005
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Differential expression patterns of the insulin-like growth factor 2 gene in human colorectal cancer. 15192314 2004
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 PosttranslationalModification disease BEFREE Our findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer. 14996863 2004