Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With the success in establishing mice nephroblastoma models through over-expressing IGF2 and deleting WT1, and advances in understanding the ENU-induced rat model, we are now able to explore the molecular and cellular mechanisms induced by these genetic, epigenetic, and miRNA alterations in animal models to understand the development of Wilms tumor.
|
25018051 |
2014 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This contrasts the situation we found at the IGF2/H19 locus, which shows high overexpression of IGF2 and inversely correlated expression of the H19 gene in WT.
|
23825673 |
2013 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic abnormalities at the IGF2/H19 locus play a key role in the onset of Wilms tumor.
|
23074036 |
2013 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first comprehensive study of the four genes, and the results supported the hypothesis that the lower incidence of IGF2 LOI contributes to the lower incidence of WTs in Japanese children.
|
22409817 |
2012 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of insulin-like growth factor 2 (IGF2), an imprinted gene located on chromosome 11p15, has been reported as a characteristic feature in various embryonal tumors, including Wilms tumor (WT).
|
21174059 |
2011 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
19293570 |
2009 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epigenetic changes occur frequently in Wilms' tumor (WT), especially loss of imprinting (LOI) of IGF2/H19 at 11p15.
|
18644976 |
2008 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Loss of imprinting (LOI) of the IGF2 gene (which encodes insulin-like growth factor II) is the most common genetic or epigenetic alteration in Wilms tumor; LOI involves aberrant activation of the normally repressed maternally inherited allele.
|
17686827 |
2007 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe a family with overgrowth in three generations and Wilms' tumor in two generations, with paternal inheritance of a cis-duplication at 11p15.5 spanning the BWS IC1 region and including H19, IGFII, INS, and TH.
|
17325026 |
2007 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
|
16518847 |
2006 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using molecular analysis, a loss of Wilms' tumor gene 1 (WT1) transcript and a biallelic expression of insulin growth factor 2 (IGF2) could be revealed.
|
16177880 |
2006 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, a genetic (16q LOH) and an epigenetic (LOI of IGF2) alteration in WT are linked, the first such association described.
|
15761865 |
2005 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues.
|
12702581 |
2003 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, some WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating that methylation of these sites is necessary but not sufficient for LOI in WT.
|
11431321 |
2001 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor.
|
11717330 |
2001 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively.
|
10731720 |
2000 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic imprinting of insulin-like growth factor 2 (IGF2) has been shown to play an important role in the development of Wilms' tumor and adult cancers including lung and esophageal cancer.
|
11053988 |
2000 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the analysis of the expression of other 11p15 imprinted genes and kidney-developmentally regulated genes indicates that IGF2 overexpression, inappropriate coexpression of RET and GDNF and, in some cases, down-regulation of CDKN1C may also play an important role in the pathogenesis of WT.
|
10749116 |
2000 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The LOI of IGF2 may induce increased or deregulated IGF2 expression which could initiate the onset of WT.
|
9589901 |
1998 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relaxation of imprinting at the insulin-like growth factor II (IFG-II)/H19 locus is a major mechanism involved in the onset of sporadic Wilms tumor and several other embryonal tumors.
|
9144243 |
1997 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The level of IGF2 expression was comparable with that of Wilms tumor.
|
9385942 |
1997 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two other 11p15.5 loci, the linked and oppositely imprinted H19 and IGF2 genes, have been previously implicated in WT pathogenesis, and several of the tumors with persistent KIP2 mRNA expression and absence of KIP2 coding mutations showed full inactivation of H19.
|
9311733 |
1997 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wilms' tumor (WT) is an embryonal renal malignancy, which overexpresses insulin-like growth factor II (IGF-II), a fetal mitogen.
|
9070652 |
1997 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Metanephric blastemal cells displayed characteristic vimentin and smooth muscle actin immunoreactivity and insulin-like growth factor II gene expression, whereas induced elements exhibited appropriate cytokeratin immunoreactivity and Wilms' tumor gene expression.
|
8642784 |
1996 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the increased expression of IGF2 in Wilms' tumor may be caused either by biallelic gene expression in LOI tumors from promoters P2-P4 and/or by a reversion to an earlier stage of development which is characterized by increased synthesis of this fetal growth factor.
|
8621549 |
1996 |