IGF2R, insulin like growth factor 2 receptor, 3482

N. diseases: 166; N. variants: 18
Disease: Fetal Growth Retardation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.240 Biomarker phenotype BEFREE IGF2R expression was significantly decreased in placentas from pregnancies complicated by idiopathic FGR (P < 0.05 versus control). siRNA-mediated IGF2R knockdown in term placental explants and the trophoblast cell line BeWo resulted in altered expression of homeobox gene transcription factors, including increased expression of distal-less homeobox gene 5 (DLX5), and decreased expression of H2.0-Like Homeobox 1 (HLX) (P < 0.05 versus control). 31418778 2019
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.240 GeneticVariation phenotype BEFREE The infant with IUGR has a higher serum level of IGF2 if has A/G IGF2-ApaI genotype and higher values of IGF2R if it has the A/A genotype. 28460554 2018
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.240 AlteredExpression phenotype BEFREE When compared to age-matched appropriate for gestational age (AGA) infants, expression of PHLDA2 (p = 0.03) IGF2R (p < 0.05) was upregulated in IUGR infants. 22154689 2012
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.240 Biomarker phenotype BEFREE There was no significant difference in the levels of transcripts for IGF1, insulin receptor, or IGF2R between normal and IUGR term placentas. 9491374 1998
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.240 Biomarker phenotype RGD Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation. 1408464 1992