|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The comparison of Cyr61 between RA patients and controls, the correlation between Cyr61 levels with disease activity, and the change of Cyr61 after treatment were analyzed by appropriate statistical analyses.
|
31113467 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A monoclonal antibody, namely, 093G9, is effective to antagonize the effects of CCN1 and hence has potential therapeutic benefits against rheumatoid arthritis.
|
28608634 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, Cyr61 directly promoted RA-FLS migration and invasion.
|
27456070 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study describes how CCN1 promotes monocyte migration by upregulating CCL2 expression in osteoblasts in RA disease.
|
28341837 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, we uncovered the Collagen II-DDR2-AP-1-CYR61-ETS1-MMP1 loop in RA FLS.
|
27653023 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study provides new evidence that Cyr61 participates in RA pathogenesis not only as a pro-inflammatory factor but also plays a key role in bone erosion via promoting MMP-3 expression.
|
27585710 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
CCN1, an extracellular protein also known as cysteine-rich protein 61 (Cyr61), is a novel pro-inflammatory factor involved in the pathogenesis of rheumatoid arthritis.
|
28266627 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study is the first to describe how CCN1 promotes VEGF expression in osteoblasts and increased EPCs angiogenesis in RA disease.
|
27465842 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results reveal a novel role of Cyr61 in RA that involves the promotion of proIL-1β production in FLS.
|
25728492 |
2015 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The study found that the Cyr61 gene was highly expressed in the synovial cells from patients with RA compared with those from patients with OA.
|
25351421 |
2015 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As a result, miR-22 was down-regulated, contributing to the overexpression of Cyr61 in RA FLS.
|
24449575 |
2014 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, CCN1 has now emerged as an important partner when targeting components of the infectious or chronic inflammatory disease processes such as atherosclerosis or rheumatoid arthritis.
|
24638890 |
2014 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration.
|
19192274 |
2009 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins.
|
16804865 |
2006 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to examine whether CCN1 can activate HSCs and affect the function of activated HSCs in promoting the progression of HCC.
|
29286082 |
2018 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that ATF3 functions as a tumor suppressor in HCC through targeting and regulating CYR61.
|
30376856 |
2018 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
By analyzing the data of GEO Database, we found that Oxa aberrantly increased the expression of Cysteine-rich61 (Cyr61) in HCC cell lines.
|
30410600 |
2018 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Consequently, Ccn1(dm/dm) mice exhibit diminished p53 activation and elevated compensatory hepatocyte proliferation, resulting in increased HCC.
|
26028023 |
2016 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found that over-expression of Cyr61 in HepG2 cells promoted the progression of HCC xenografts in SCID mice.
|
22540002 |
2012 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Cyr61 expression was down-regulated in HCC tumors as measured by quantitative real-time PCR and its protein level was decreased in most HCC cell lines as detected by Western blot.
|
17698398 |
2008 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors.
|
17699798 |
2007 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
LHGDN |
An examination of the d(CA) dinucleotide patterns in the Cyr61 promoter in HCC patients revealed that approximately 32% of these patients exhibited either loss of heterozygosity or somatic mosaicism in either the tumors, adjacent normal liver tissues or both.
|
15782120 |
2005 |
|
Liver carcinoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
An examination of the d(CA) dinucleotide patterns in the Cyr61 promoter in HCC patients revealed that approximately 32% of these patients exhibited either loss of heterozygosity or somatic mosaicism in either the tumors, adjacent normal liver tissues or both.
|
15782120 |
2005 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
LHGDN |
The expressions of Cyr61 and CTGF mRNA in HCC with venous invasion were higher than those in HCC without venous invasion.
|
15526358 |
2004 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
The expressions of Cyr61 and CTGF mRNA in HCC with venous invasion were higher than those in HCC without venous invasion.
|
15526358 |
2004 |