APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Plaque, Amyloid ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 AlteredExpression disease BEFREE To study the effect of amyloid deposits on cell cycle related events in vivo, the expression of cell cycle markers was examined by immunohistochemistry in amyloid precursor protein (APP) transgenic mice (APP23 mice, Swedish double mutation). 12923647 2003
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE It is also possible that the human APP gene responsible for HSD-10 deposition in APs of these Tg2576 mice brains is different from that of AD brains. 12393239 2002
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Transgenic designs emphasizing amyloid precursor protein produced mice that develop amyloid plaques, but neurodegeneration and neurofibrillary tangles failed to form. 11917160 2002
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The central component of senile amyloid plaques in Alzheimer's disease (AD) is the beta-amyloid peptide (Abeta), derived from proteolytic processing of the amyloid precursor protein (APP). 11421596 2001
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Here, we describe significant CAA in addition to amyloid plaques, in aging APP/Ld transgenic mice overexpressing the London mutant of human amyloid precursor protein (APP) exclusively in neurons. 11021833 2000
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE The transmembrane domain and a portion of the C-terminus (A beta) of the amyloid precursor protein, are known to form the nucleus of the amyloid plaque. 10192224 1999
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The amyloid precursor protein (APP) has been associated with Alzheimer's disease (AD) because APP is processed into the beta-peptide that accumulates in amyloid plaques, and APP gene mutations can cause early onset AD. 10037734 1999
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The increased expression and/or abnormal processing of the amyloid precursor protein (APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid deposits, which are one of the major morphological hallmarks of Alzheimer's disease (AD). 9775403 1998
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 AlteredExpression disease BEFREE Models of AD include: aged monkeys that show both cognitive/memory deficits and cellular abnormalities (amyloid deposition/cytoskeletal abnormalities of neurons) in cortex and hippocampus; and Tg mice that express mutant human FAD-linked genes (i.e., APP and PS1) and show increased levels of A.42, amyloid deposits, dystrophic neurites, and local responses of astrocytes and microglia. 9683997 1997
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE In this report, we demonstrate that transgenic animals that coexpress a FAD-linked human PS1 variant (A246E) and a chimeric mouse/human APP harboring mutations linked to Swedish FAD kindreds (APP swe) develop numerous amyloid deposits much earlier than age-matched mice expressing APP swe and wild-type Hu PS1 or APP swe alone. 9354339 1997
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The main component of senile plaque amyloid is a 39-to 42-amino-acid segment referred to as beta-amyloid, which is derived from amyloid precursor protein (APP). 8809275 1996
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The 4-kDa beta-amyloid peptide (Abeta), a principal component of parenchymal amyloid deposits in Alzheimer's disease, is derived from amyloid precursor proteins (APP). 8621605 1996