Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE Abnormal production of amyloid-β peptides (Aβ) by proteolytic processing of amyloid precursor protein (APP) is thought to be central to the pathogenesis of Alzheimer's disease (AD). 29080748 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice. 28743230 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 AlteredExpression disease BEFREE Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. 28477083 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE The role of neuroinflammation and amyloid in cognitive impairment in an APP/PS1 transgenic mouse model of Alzheimer's disease. 28191738 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 AlteredExpression disease BEFREE Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice. 28637503 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE Genetic and pathologic data suggest that amyloid beta (Aβ), produced by processing of the amyloid precursor protein, is a major initiator of Alzheimer's disease (AD). 28817954 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 GeneticVariation disease BEFREE Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide. 28049728 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage product, is a leading hypothesis in the etiology of Alzheimer's disease (AD). 28985224 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 AlteredExpression disease BEFREE Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology. 28417423 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 GeneticVariation disease BEFREE The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis". 28054745 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE Sortilin receptor 1 (SORL1) is involved in cellular trafficking of amyloid precursor protein and plays an essential role in amyloid-beta peptide generation in Alzheimer disease (AD). 26996954 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid () found in senile plaques. 29018038 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE The pathological hallmark of Alzheimer's disease (AD) is associated with the accumulation of amyloid-β (Aβ) derived from proteolytic processing of amyloid-β precursor protein (APP). 28624365 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production. 28096459 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE AD is associated with aberrant processing of the amyloid precursor protein, which leads to the deposition of amyloid-β plaques within the brain. 27340665 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 GeneticVariation disease BEFREE This is the first report to show decreased levels in plasma in APP A673T carriers and thus provides evidence that lower levels throughout life may be protective against AD.Ann Neurol 2017;82:128-132. 28556232 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 AlteredExpression disease BEFREE We found that DAC and TSA had different effects on the expression trends of SIRT1 and APP in the cell model of amyloid toxicity. 27522594 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE The amyloid precursor protein (APP) has been extensively investigated for its role in the production of amyloid beta (Aβ), a plaque-forming peptide in Alzheimer's disease (AD). 28710249 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE BACE 1 is a protease that cleaves the transmembrane amyloid precursor protein and generates amyloid-β peptides that accumulate in AD brains. 28817311 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 GeneticVariation disease BEFREE Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid () peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS). 26651340 2016
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE We investigated the genetic main effects and interaction effects on cingulate amyloid-beta (Aβ) load in an effort to better understand the genetic etiology of Aβ deposition that is a widely studied AD biomarker. 26421299 2016
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside. 26429731 2016
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 GeneticVariation disease BEFREE A mouse model, containing five human familial AD genes (5XFAD), also develops plaques with BChE activity. 25931333 2016
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE Recent work has suggested that GSK3β also plays a role in the amyloid pathway of AD through genetic interactions with APP and APBB2 on in vivo measures of amyloid. 26194614 2016
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.400 Biomarker disease BEFREE ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation. 26002056 2016