|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Here, we investigated the roles of NDRG2 in the development of memory impairment in AD using mouse models established by amyloid β injection or crossing of APP/PS1 mice.
|
31778735 |
2020 |
|
Forgetful
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
More severe learning and memory impairment and higher Aβ1-40 expression in brain and plasma were detected in the APP/PS1 mice of 27-OHC treatment group.
|
30582229 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibitory parvalbumin (PV) interneurons importantly contributes to neuronal network dysfunction and memory impairment in APP/PS1 mice, a mouse model of increased amyloidosis.
|
31431685 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Restraint/isolation stress induced significant depressive-like behaviors in APP/PS1 mice at 4 months of age and memory impairment at 10 months of age, while 6 months of icariin administration relieved the memory damage.
|
31001073 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Therefore, we also investigated the dynamic of other protein markers involved in cognition and memory impairment such as metabotropic glutamate receptor 5 (mGluR5), ionotropic NMDA receptor (NMDAR2B), prion protein (PrPc) and amyloid precursor protein (APP), whose activity depends on membrane lipid organization.
|
31068782 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway.
|
30774310 |
2019 |
|
Forgetful
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
We show that prolonged treatment with selegiline fails to reduce aberrant astrocytic GABA levels and rescue memory impairment in APP/PS1 mice, an animal model of AD, because of increased activity in compensatory genes for a GABA-synthesizing enzyme, diamine oxidase (DAO).
|
30906861 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Moreover, while promoting apoE interaction with APP by ApoEp exacerbated Aβ and tau brain pathologies in 3XTg-AD mice, disrupting this interaction by 6KApoEp ameliorated cerebral Aβ and tau pathologies, neuronal apoptosis, synaptic loss, and hippocampal-dependent learning and memory impairment in 5XFAD mice without altering cholesterol, low-density lipoprotein receptor, and apoE expression levels.
|
31208706 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Moreover, JuA suppresses SD-induced enhancement of mEPSCs and prevents memory impairment in APP/PS1 mice.
|
30872728 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
MCH improved memory impairment in both models and reduced soluble amyloid beta in the cerebral cortex of APP/PS1 transgenic mice.
|
31183806 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.
|
30871577 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
We demonstrated that MSe-Res/Fc-β-CD/Bor inhibited aggregation of β-amyloid proteins (Aβ), mitigated oxidative stress, and suppressed tau hyperphosphorylation, while protecting nerve cells and successfully improving memory impairment in APP/PS1 mice.
|
30638753 |
2019 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The results demonstrated that EA treatment ameliorated spatial learning and memory impairment in APP/PS1 mice and significantly reduced neuronal apoptosis and Aβ deposition in the hippocampus (P<0.05 and P<0.01).
|
30542451 |
2018 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice.
|
29253574 |
2018 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The memory impairment associated to APP/PS1 transgene was accelerated in these mice.
|
30096288 |
2018 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Flavonoids extracted from leaves of Diospyros kaki regulates RhoA activity to rescue synapse loss and reverse memory impairment in APP/PS1 mice.
|
29481523 |
2018 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Our data demonstrated that xanthoceraside may promote the proliferation and differentiation of NSCs into neurons by up-regulating the Wnt/β-catenin pathway to fill the neuronal loss, thereby improving learning and memory impairment in APP/PS1 transgenic mice.
|
28744803 |
2018 |
|
Forgetful
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
We found that oral treatment with FLDK reversed learning and memory impairment, reduced Aβ burden and expression of β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and decreased microglial activation in senile plaques.
|
29038004 |
2018 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Although the primary causes of these disturbances are still under investigation, a growing body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal fragment β (C99), generated by cleavage of APP by β-site APP cleaving enzyme 1 (BACE-1), is the primary cause of the endosome enlargement in AD and the earliest initiator of synaptic plasticity and long-term memory impairment.
|
28254759 |
2017 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Second, we used an APPswe/PS1E9 (APP/PS1) double transgenic mice to evaluate the amelioration ability of simvastatin against the memory impairment in vivo.
|
28528185 |
2017 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
We investigated the pharmacological potential of YY-1224 in β-amyloid (Aβ) (1-42)-induced memory impairment using cyclooxygenase-2 (COX-2) knockout (-/-) and APPswe/PS1dE9 transgenic (APP/PS1 Tg) mice.
|
28449688 |
2017 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Exposure of isoflurane exhibited significant neuroapoptosis, Aβ generation, tau phosphorylation, and learning and memory impairment in APP/PS1 mice in the presence of Zn deficiency.
|
27586008 |
2016 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Here, we show that xanthoceraside at doses of 0.08 and 0.32 mg/kg/d for 6 months significantly improved learning and memory impairment in APP transgenic mice assessed by the Y maze and novel object recognition tests.
|
24810883 |
2014 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Amyloid-β peptide 42 (Aβ42) is produced through the sequential proteolytic cleavage of APP by β- and γ-secretase and causes the synaptic dysfunction associated with memory impairment in Alzheimer's disease.
|
24373902 |
2014 |
|
Forgetful
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
In contrast, C57 APP/PS1 and SAMP8 wild type mice were inconspicuous in all of these tasks and properties except C57 APP/PS1 mice which showed motor memory impairment in the shuttle box task at 9 months old.
|
24095271 |
2013 |