Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 Biomarker disease CTD_human Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. 25288670 2016
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 Biomarker disease BEFREE MCI participants diagnosed via neuropsychological criteria yielded dissociable cognitive phenotypes, significant CSF AD biomarker associations, more stable diagnoses, and identified greater percentages of participants who progressed to dementia than conventional MCI diagnostic criteria. 24844687 2015
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 Biomarker disease BEFREE Abnormal CSF-AD biomarker levels predict subsequent progression to AD dementia in subjects with early-onset MCI. 24577466 2015
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 Biomarker disease BEFREE Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease. 21954051 2012
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 AlteredExpression disease BEFREE There was a significant positive correlation between sAPPα and sAPPβ levels in all three groups. sAPPα and sAPPβ concentrations were higher in patients with mild cognitive impairment compared with patients with AD. 22055653 2012
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 GeneticVariation disease BEFREE Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment. 20648652 2011
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 Biomarker disease BEFREE Because both mild cognitive impairment and Alzheimer's disease generally occur in elderly individuals, the age group that commonly present for CABG, we investigated if the APOE epsilon4 allele was associated with patients manifesting preexisting cognitive impairment and postoperative cognitive dysfunction. 18721571 2008
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder
0.370 GeneticVariation disease BEFREE To determine the spectrum of mutations in a group consisting of 40 Polish patients with clinically diagnosed familial EOAD and 1 patient with mild cognitive impairment (MCI) and family history of AD, we performed a screening for mutations in the presenilin 1 (PSEN1), presenilin 2 (PSEN2) and amyloid precursor protein (APP) genes. 14769392 2004