Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In our population, there is no evidence that the IL1 beta gene is involved in schizophrenia.
|
9323321 |
1997 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genes for interleukin-2 receptor beta chain, interleukin-1 beta, and schizophrenia: no evidence for the association or linkage.
|
9184320 |
1997 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
One indication of the pathogenic role of IL-1 in schizophrenia would be a demonstration of the difference between schizophrenic patients and healthy controls at the gene level.
|
10208450 |
1999 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The data suggest that allele 2 within the promoter region of the interleukin-1beta gene at position -511 contributes to structural brain alterations in patients with schizophrenia.
|
11481169 |
2001 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the second part of the study, three polymorphisms at the Interleukin-1 gene cluster (IL-1, chromosome 2q13-q21) were investigated in both cohorts, since associations with schizophrenia have been reported in another sample.
|
11423178 |
2001 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.
|
12706488 |
2003 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the contribution of IL-1 signaling to the brain pathology of schizophrenia, we measured protein and/or mRNA levels for IL-1beta and endogenous IL-1 receptor antagonist (IL-1RA) in the postmortem brain tissues of prefrontal and parietal cortex, putamen, and hypothalamus.
|
12804791 |
2003 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1beta (IL-1beta) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders.
|
14681906 |
2004 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings support the hypothesis that genetically determined changes in IL-1 metabolism regulation may contribute to the pathogenesis of schizophrenia confirming a role of IL-1 gene cluster in disease susceptibility.
|
14563376 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms associated with neuropsychiatric disorders such as schizophrenia and Alzheimer's disease have been reported at the interleukin-1 (IL-1) panel.
|
14997019 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because there is increasing interest in the common disruption of cytokine pathways seen in both AD and schizophrenia, we tested the association between the functional interleukin-1beta -511 promoter polymorphism with delusions and hallucinations in AD.
|
15236409 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder.
|
15318032 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder.
|
14985387 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41).
|
16905295 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data do not suggest that genetically determined changes in the IL-1 gene complex confer increased susceptibility for schizophrenia.
|
16856121 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous reports have shown the influence of genes mapped to IL-1 cluster (i) in the risk to develop schizophrenia and (ii) on brain morphological abnormalities in these patients.
|
17510951 |
2007 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the effects of the IL-1beta gene (IL-1B) -511 and NRG-1 SNP8NRG221533 polymorphisms and their interactions on the risk and age of onset of schizophrenia in 113 Finnish schizophrenic patients and 393 healthy controls.
|
17901998 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings support the hypothesis of IL-1 cluster variability as a shared genetic risk factor contributing to GM deficits both in bipolar disorder and in schizophrenia.
|
19125864 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
LHGDN |
We studied the effects of the IL-1beta gene (IL-1B) -511 and NRG-1 SNP8NRG221533 polymorphisms and their interactions on the risk and age of onset of schizophrenia in 113 Finnish schizophrenic patients and 393 healthy controls.
|
17901998 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study suggests the IL1B gene or the IL1 gene complex may play a moderate role in the etiology of schizophrenia in the Caucasian population.
|
20347268 |
2010 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to profile the peripheral biomarkers (tyrosine hydroxylase, TH; interleukin-1beta, IL-1beta; and tumor necrosis factor-alpha, TNF-alpha) for schizophrenia and explore their relations with clinical symptoms.
|
20067853 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study shows the first evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population.
|
21843369 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The findings support a role for IL1B variability in the dorsolateral prefrontal cortex dysfunction classically associated with schizophrenia.
|
22763186 |
2012 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results appear to support the previous hypothesis that IL1B contributes to the genetic risk of schizophrenia and warrant further research on the association of eQTL SNPs with schizophrenia.
|
22804923 |
2012 |