Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1beta (IL-1beta) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders.
|
14681906 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because there is increasing interest in the common disruption of cytokine pathways seen in both AD and schizophrenia, we tested the association between the functional interleukin-1beta -511 promoter polymorphism with delusions and hallucinations in AD.
|
15236409 |
2004 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Case-treatment analyses revealed significant interactions between bipolar case status and IL-1β, IL-6, IFN-γ + TNF-α, or IFN-γ + IL-1β, as well as between schizophrenia case status and IL-1β, IFN-γ + TNF-α, or IFN-γ + IL-1β, in terms of higher 3-HK.
|
24012176 |
2013 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CSF levels of IL-1β and kynurenic acid were significantly increased in patients with schizophrenia and bipolar disorder compared to healthy controls (P < .001).
|
28338954 |
2018 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, psychotic symptoms were positively related to IL-1β levels in individuals with schizophrenia.
|
29803226 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genes for interleukin-2 receptor beta chain, interleukin-1 beta, and schizophrenia: no evidence for the association or linkage.
|
9184320 |
1997 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41).
|
16905295 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder.
|
15318032 |
2004 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In our population, there is no evidence that the IL1 beta gene is involved in schizophrenia.
|
9323321 |
1997 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the second part of the study, three polymorphisms at the Interleukin-1 gene cluster (IL-1, chromosome 2q13-q21) were investigated in both cohorts, since associations with schizophrenia have been reported in another sample.
|
11423178 |
2001 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder.
|
14985387 |
2004 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It has been revealed that the levels of interleukin 1β (IL-1β), IL-6, IL-8, and TNF-α were increased in patients with Scz.
|
29680514 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mean log transformed values of TNF-α, (p=.029) and IL-1β (p=.016) were over twofold higher in people with schizophrenia who had high levels of AGA IgG (≥7 U) compared to those who did not have positivity to AGA IgG.
|
29074356 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, recent studies suggested that IL-1 participates in the progression of lung disease in smokers, which are overrepresented in schizophrenia.
|
25858413 |
2015 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
One indication of the pathogenic role of IL-1 in schizophrenia would be a demonstration of the difference between schizophrenic patients and healthy controls at the gene level.
|
10208450 |
1999 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data do not suggest that genetically determined changes in the IL-1 gene complex confer increased susceptibility for schizophrenia.
|
16856121 |
2006 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings support the hypothesis that genetically determined changes in IL-1 metabolism regulation may contribute to the pathogenesis of schizophrenia confirming a role of IL-1 gene cluster in disease susceptibility.
|
14563376 |
2004 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results appear to support the previous hypothesis that IL1B contributes to the genetic risk of schizophrenia and warrant further research on the association of eQTL SNPs with schizophrenia.
|
22804923 |
2012 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.
|
12706488 |
2003 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study suggests the IL1B gene or the IL1 gene complex may play a moderate role in the etiology of schizophrenia in the Caucasian population.
|
20347268 |
2010 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Positive correlation was observed between KYN and IL-1β only in the schizophrenia group (r = 0.461, p = 0.021).
|
29306989 |
2018 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous reports have shown the influence of genes mapped to IL-1 cluster (i) in the risk to develop schizophrenia and (ii) on brain morphological abnormalities in these patients.
|
17510951 |
2007 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms associated with neuropsychiatric disorders such as schizophrenia and Alzheimer's disease have been reported at the interleukin-1 (IL-1) panel.
|
14997019 |
2004 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to profile the peripheral biomarkers (tyrosine hydroxylase, TH; interleukin-1beta, IL-1beta; and tumor necrosis factor-alpha, TNF-alpha) for schizophrenia and explore their relations with clinical symptoms.
|
20067853 |
2010 |