|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A higher number of pro-inflammatory cytokine risk alleles, and IL-1β-511T/T genotype individually, were independently associated with both prevalent depression at baseline and persistent depression at one year follow-up.
|
23276701 |
2013 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although 5-ASA is a known anti-inflammatory agent, neither treatment with SSZ nor 5-ASA/SP prevented tumour-induced increases in serum levels of interleukin-1β (IL-1β) and IL-6, which are indicated in depressive disorders.
|
28120908 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the IL-1 molecules are traditionally considered to be classical proinflammatory cytokines, their functions are not restricted to inflammation, and they have also been shown to play a key role in a wide range of additional physiological and pathological functions, including learning modulation, sleep, pregnancy, depression, appetite, hematopoiesis, metabolism, and many others.
|
29247999 |
2018 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
At week 4, fatigue (<i>p</i>=0.023) and depression (<i>p</i>=0.007) responders had less decrease in IL-1 level than the corresponding non-responders.
|
28203105 |
2017 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores.
|
30616482 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic peripheral inflammation mediated by cytokines such as TNFα, IL-1β, and IL-6 is associated with psychiatric disorders like depression and anxiety.
|
26074461 |
2015 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078-1.206; significant heterogeneity: I<sup>2</sup> = 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156-0.598; significant heterogeneity: I<sup>2</sup> = 88.75%) were significantly elevated in depression.
|
30104698 |
2018 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correlation analysis between HADS score and cytokine serum levels revealed positive associations of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α, and a negative correlation with IL-10, suggesting that cytokines are involved in the pathophysiology of these psychological disorders in CRC patients.
|
28969939 |
2018 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correlation analysis revealed that depression severity negatively correlated with IL-12 in males, and positively correlated with IL-1β and tumor necrosis factor (TNF)-α in females.
|
28670290 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevations in brain interleukin-1 beta (IL-1β) during chronic stress exposure have been implicated in behavioral and cognitive impairments associated with depression and anxiety.
|
30711897 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, the effects of chronic stress on both depression- and anxiety-like behaviors can be mimicked by exogenous intracerebroventricular (i.c.v.) administration of IL-1β in both WT and Caspase-1<sup>-/-</sup> mice.
|
28416811 |
2018 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Findings across the literature suggest that functional allelic variants of genes for interleukin-1beta (IL)-1β, tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP), as well as genetic variations affecting T-cell function, may increase the risk for depression.
|
22580182 |
2013 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, IL-1β, which can regulate inflammatory responses, has also been associated with depression.
|
26750863 |
2016 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, mGluR5 deficiency dramatically inhibits cytokines release from bone marrow cells, such as IL-1β, TNF-α and IL-6, alleviating proinflammatory responses in LPS-induced depression model.
|
30682501 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Ghrelin effects expression of several genes associated with depression-like behavior.
|
25286107 |
2015 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Given substantial evidence for IL-1beta involvement in the etiology of depression, the IL1B gene is a strong candidate for involvement in susceptibility to depressive disorders.
|
19016479 |
2009 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments.
|
28948716 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-6 was elevated in DEP and DEP-T adolescents compared to controls (p = .014) and TNF-α was elevated in DEP participants only (p = .040) compared to controls, whereas no group differences were found in IL-1β (p = .829).
|
30978658 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a 2-year prospective study of a community sample of 521 older people, information on number of physical disorders, diagnosis of depression (Geriatric Mental State), and genotypes for 6 pro-inflammatory (tumor necrosis factor-α -850C/T and -308G/A, interleukin (IL)-1β -511C/T and +3953C/T, IL-6 -174G/C, IL-8 -251T/A) and 2 anti-inflammatory (IL-4 +33T/C, IL-10 -1082G/A) cytokine polymorphisms were ascertained.
|
22921153 |
2013 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In all subjects, the IL-1β levels were correlated with PCL scores, after controlling for covariates, including age, education, marital status and gender, trauma exposure severity and depression.
|
30711869 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results of the present study suggested that AT-I exerts anti-depressant-like effects in a CUMS-induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL-1β production.
|
29434743 |
2018 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In recent years, proinflammatory cytokine interleukin-1β (IL-1β) was considered to play a critical role in the pathogenesis of depression.
|
28486969 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the rat depression model, depression decreased tear secretion and increased IL-1β and TNF-α production, whereas the serotonin, TLR2, and TLR4 levels were not increased.
|
30695093 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the rat model and human cirrhosis a proinflammatory cytokine pattern (elevation of interferon gamma, interleukin [IL]-1β, IL-6) was registered which in humans correlated to the degree of HE and depression.
|
31170723 |
2019 |